Biphasic Increase of Epithelial DNA Synthesis in the Urinary Bladder of Rats Treated with a Tumor Promoter, Sodium L-ascorbate
スポンサーリンク
概要
- 論文の詳細を見る
Sequential changes in the levels of DNA synthesis in urinary bladder epithelium following administration of a rat tumor promoter, sodium L-ascorbate (Na-AsA) for 8 weeks were examined. Male 6-week-old F344 rats were allocated into 4 groups, and given powdered basal diet containing Na-AsA at concentrations of 0 (control), 1.25, 2.5 or 5.0%. The 5-bromo-2-deoxyuridine (BrdU) labeling index in bladder epithelium in the treated groups increased at week 1, but returned to low levels between weeks 2 and 6, and increased at week 8 once again, essentially with dose dependency. The epithelium of the urinary bladder appeared normal at weeks 1 and 2, but slight simple hyperplasia was observed at weeks 4, 6 and 8 with a dose-dependent response. Our results demonstrate that the early DNA synthesis induced in the rat bladder epithelium by Na-AsA is biphasic in nature.
- 日本毒性病理学会の論文
- 2006-03-01
著者
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FUKUSHIMA Shoji
Department of Pathology, Osaka City University Medical School
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MORIMURA Keiichirou
Department of Pathology, Osaka City University Medical School
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WEI Min
Department of Pathology, Osaka City University Medical School
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Fukushima S
Japan Bioassay Research Center Japan Industrial Safety And Health Association
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Wei Min
Department Of Pathology Osaka City University Medical School
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Morimura K
Department Of Pathology Osaka City University Medical School
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Morimura Keiichirou
大阪市立大学 医学部都市医学
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Morimura Keiichirou
Department Of Pathology Osaka City University Medical School
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Chen Tianxin
大阪市立大学 医学部都市医学
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Chen T
First Department Of Pathology Osaka City University Medical School
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KITANO Mitsuaki
First Department of Pathology, Osaka City University Medical School
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Fujiwara Yushi
Department Of Surgery Osaka City Juso Hospital
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Chen Tianxin
Department Of Pathology Osaka City University Medical School
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HIDAKA Takayoshi
Pharmacology and Toxicology Group, Life Science Research Laboratories, Life Science RD Center, Kanek
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HOSOE Kazunori
Pharmacology and Toxicology Group, Life Science Research Laboratories, Life Science RD Center, Kanek
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KITANO Mitsuaki
Department of Pathology, Osaka City University Medical School
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CHEN Tian-Xin
Department of Pathology, Osaka City University Medical School
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Hidaka Takayoshi
Pharmacology And Toxicology Group Life Science Research Laboratories Life Science Rd Center Kaneka C
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Hosoe Kazunori
Pharmacology And Toxicology Group Life Science Research Laboratories Life Science Rd Center Kaneka C
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Kitano M
First Department Of Pathology Osaka City University Medical School
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Kitano Mitsuaki
Department Of Pathology Osaka City University Medical School
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Fukushima Shoji
中央労働災害防止協会日本バイオアッセイ研究センター
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Wei Min
Department Of Food Science Obihiro University Of Agriculture And Veterinary Medicine
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Fukushima Shoji
Japan Bioassay Research Center
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Fukushima Shoji
Dept. Pathol. Osaka City University Medical School
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Fukushima Shoji
Department Of Pathology Osaka City University Medical School
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Kitano Mitsuaki
Takasago Research Laboratories Research Institute Kaneka Corporation
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Fukuhara Kennichirou
Department Of Gastroenterological Surgery Osaka City University Graduate School Of Medicine
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Min Wei
Department Of Pathology Osaka City University Medical School
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Fukushima Shoji
Department Of Gastroenterological Surgery Osaka City University Graduate School Of Medicine
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