Transdermal Drug Delivery by Electroporation Applied on the Stratum Corneum of Rat Using Stamp-Type Electrode and Frog-Type Electrode in Vitro

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概要

• 論文の詳細を見る

• Transdermal enhancement effects of electroporation applied only on the stratum corneum by two electrode types, the stamp-type electrode and the frog-type electrode, were investigated in vitro using excised rat skin. Carboxyfluorescein(CF)was selected as a model compound. The excised skin was set in a Franz type diffusion cell and a square wave electric pulse was applied to the stratum corneum under various electric pulse conditions. We determined the permeability of CF to the receptor compartment under these conditions. Voltage, electric pulse length, and number of electric pulses, were varied from 10 to 1000V, 50μs to 15ms and 5 to 30 pulses, respectively. Flux rate was enhanced as the electric pulse condition strengthened. However, the maximum value was attained in the flux rate, above which no increase was observed despite strengthening of the electric pulse. Although at low electric pulses, the enhancement effect of the frog-type electrode was superior to that of the stamp-type electrode, the maximum flux rates were the same. These results indicate that electroporation on the stratum corneum using the stamp-type electrode or frog-type electrode, is useful for transdermal drug delivery.

• 社団法人日本薬学会の論文
• 2001-09-01

著者

• 竹内 洋文

  50周年誌編集小委員会

• FUKUSHIMA Shoji

  Department of Pathology, Osaka City University Medical School

• Fukushima S

  Lab. Of Clinical Pharmaceutics Fac. Of Pharmaceutical Sciences Kobe Gakuin Univ.

• Takeuchi Yoshikazu

  Lab. Of Clinical Pharmaceutics Fac. Of Pharmaceutical Sciences Kobe Gakuin Univ.

• KISHIMOTO Shuichi

  Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Kobe Gakuin University

• KAWAZOE Yuji

  Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Kobe Gakuin University

• TAKEUCHI Yoshikazu

  Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Kobe Gakuin University

• HORAI Shigeki

  Department of Pharmaceutics, Faculty of Pharmaceutical Science, Kobe Gakuin University

• MIYAWAKI Kohji

  Department of Pharmaceutics, Faculty of Pharmaceutical Science, Kobe Gakuin University

• KAMIYABU Satoshi

  Department of Pharmaceutics, Faculty of Pharmaceutical Science, Kobe Gakuin University

• KAMATA Yuri

  Department of Pharmaceutics, Faculty of Pharmaceutical Science, Kobe Gakuin University

• YAMAOKA Yumiko

  Department of Pharmaceutics, Faculty of Pharmaceutical Science, Kobe Gakuin University

• 竹内 義雄

  富山大院医薬

• 竹内 豊

  Research Center Sumitomo Pharmaceuticals Co. Ltd.

• Takeuchi Yoshikazu

  Department Of Pharmaceutics Faculty Of Pharmaceutical Sciences Kobe Gakuin University

• Kishimoto Shuichi

  Department Of Pharmaceutics Faculty Of Pharmaceutical Sciences Kobegakuin University

• Kishimoto Shuichi

  Department Of Pharmaceutics Faculty Of Pharmaceutical Sciences Kobe Gakuin University

• Takeuchi Y

  Faculty Of Pharmaceutical Sciences Okayama University

• Miyawaki Kohji

  Department Of Pharmaceutics Faculty Of Pharmaceutical Science Kobe Gakuin University

• Yamaoka Takashi

  Pharmacology Research Laboratories Dainippon Sumitomo Pharma Co. Ltd

• Horai Shigeki

  Department Of Pharmaceutics Faculty Of Pharmaceutical Science Kobe Gakuin University

• Kamata Y

  Department Of Pharmaceutics Faculty Of Pharmaceutical Sciences Kobe Gakuin University

• Takeuchi Y

  Research Center Sumitomo Pharmaceuticals Co. Ltd.

• Yamaoka Y

  Kobe‐gakuin Univ. Kobe Jpn

• Yamaoka Yumiko

  Faculty Of Pharmaceutical Sciences And High-technology Research Center Kobe-gakuin University

• Kamiyabu Satoshi

  Department Of Pharmaceutics Faculty Of Pharmaceutical Science Kobe Gakuin University

• Fukushima Shoji

  Department Of Pathology Osaka City University Medical School

• Fukushima Shoji

  Department Of Gastroenterological Surgery Osaka City University Graduate School Of Medicine

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