Intramolecular Michael Reaction in Diastereoselective Synthesis of dl-Griseofulvin

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概要

• 論文の詳細を見る

• The diastereoselective cyclization of 2a to 5a, which was employed in our novel synthesis of dl-griseofulvin (7a), was studied in detail. It was found that the use of the metallic bases resulted in excellent diastereoselectively, whereas organic bases are ineffective for diastereoselective cyclization. Consequently, diastereoselective cyclization of 2 to 5 was proposed to proceed through the intramolecular Michael reaction under chelation control.

• 公益社団法人日本薬学会の論文
• 1991-11-25

著者

• 竹内 洋文

  50周年誌編集小委員会

• Takeuchi Yoshikazu

  Lab. Of Clinical Pharmaceutics Fac. Of Pharmaceutical Sciences Kobe Gakuin Univ.

• Yamato M

  Okayama Univ. Science Okayama Jpn

• Yamato M

  Faculty Of Science Okayama University Of Science

• TAKEUCHI Yasuo

  Faculty of Pharmaceutical Sciences, Okayama University

• Yamaoka Takashi

  Pharmacology Research Laboratories Dainippon Sumitomo Pharma Co. Ltd

• Takeuchi Y

  Research Center Sumitomo Pharmaceuticals Co. Ltd.

• Watanabe I

  Department Of Pharmacognosy Faculty Of Pharmaceutical Sciences Toho University

• YAMATO Masatoshi

  Faculty of Pharmaceutical Sciences, Okayama University

• WATANABE Ikuo

  Faculty of Pharmaceutical Sciences, Okayama University

• HASHIGAKI Kuniko

  Faculty of Pharmaceutical Sciences, Okayama University

• TOMOZANE Hideo

  Faculty of Pharmaceutical Sciences, Okayama University

• Tomozane H

  Faculty Of Pharmaceutical Sciences Okayama University

• Hashigaki K

  Faculty Of Pharmaceutical Sciences Okayama University

• Hashigaki Kuniko

  Faculty Of Pharmaceutical Sciences Okayama University

• Yamato Masatoshi

  Faculty Of Pharmaceutical Sciences Okayama University

• Takeuchi Yasuo

  Faculty Of Pharmaceutical Sciences Okayama University

• Hashigaki Kuniko

  Faculty Of Pharmaceutical Sciences Okayama University:cancer Chemotherapy Center

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