Synthesis and Antitumor Activity of Fused Quinoline Derivatives. V. Methylindolo[3,2-b]quinolines

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概要

• 論文の詳細を見る

• Indolo[3,2-b]quinoline derivatives (1b-i) with a methyl group at each possible position have been synthesized. The 1-methyl (1b) and 9-methyl (1i) derivatives were inactive, but the 3-methyl (1d), 4-methyl (1e), and 6-methyl (1f) derivatives exhibited high treatment/control (T/C) value and cure rates against leukemia P388 in mice. These results indicated that modification of indolo[3,2-b]quinoline derivatives at 3,4,and 6 positions may be useful approach for lead optimization.

• 公益社団法人日本薬学会の論文
• 1997-12-15

著者

• 竹内 洋文

  50周年誌編集小委員会

• Takeuchi Yoshikazu

  Lab. Of Clinical Pharmaceutics Fac. Of Pharmaceutical Sciences Kobe Gakuin Univ.

• 原山 尚

  Faculty Of Pharmaceutical Sciences Kyoto University

• Yamato M

  Okayama Univ. Science Okayama Jpn

• Yamato M

  Faculty Of Science Okayama University Of Science

• 竹内 豊

  Research Center Sumitomo Pharmaceuticals Co. Ltd.

• TAKEUCHI Yasuo

  Faculty of Pharmaceutical Sciences, Okayama University

• HARAYAMA Takashi

  Faculty of Pharmaceutical Sciences, Okayama University

• Takeuchi Y

  Faculty Of Pharmaceutical Sciences Okayama University

• Yamaoka Takashi

  Pharmacology Research Laboratories Dainippon Sumitomo Pharma Co. Ltd

• Takeuchi Y

  Research Center Sumitomo Pharmaceuticals Co. Ltd.

• Chang M‐r

  Faculty Of Pharmaceutical Sciences Okayama University

• Harayama Takashi

  Faculty Of Pharmaceutical Sciences Okayama University

• KITAOMO Masayuki

  Faculty of Pharmaceutical Sciences, Okayama University

• CHANG Ming-rong

  Faculty of Pharmaceutical Sciences, Okayama University

• SHIRASAKA Shota

  Faculty of Pharmaceutical Sciences, Okayama University

• SHIMAMURA Chinami

  Faculty of Pharmaceutical Sciences, Okayama University

• OKUNO Yumiko

  Faculty of Pharmaceutical Sciences, Okayama University

• YAMATO Masatoshi

  Faculty of Pharmaceutical Sciences, Okayama University

• Okuno Yumiko

  Faculty Of Pharmaceutical Sciences Okayama University

• Shirasaka Shota

  Faculty Of Pharmaceutical Sciences Okayama University

• Yamato Masatoshi

  Faculty Of Pharmaceutical Sciences Okayama University

• Kitaomo Masayuki

  Faculty Of Pharmaceutical Sciences Okayama University

• Shimamura Chinami

  Faculty Of Pharmaceutical Sciences Okayama University

• Takeuchi Yasuo

  Faculty Of Pharmaceutical Sciences Okayama University

• Harayama Takashi

  Faculty of Pharmaceutical Sciences at Kagawa Campus, Tokushima Bunri University

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