Syntheses and Antifungal Activity of dl-Griseofulvin and Its Congeners. II

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概要

• 論文の詳細を見る

• Griseofulvin derivatives, dl-6'-demethyl-6'-ethylgriseofulvin (dl-5) and dl-6'-demethyl-6'-phenylgriseofulvin (dl-6) were prepared by application of a synthetic method developed by us. Antifungal activity of these derivatives decreased in the order of dl-griseofulvin (dl-1)>dl-5≫dl-6 (inactive). The reaction of these derivatives with ethanethiol gave two types of compounds, 2'-(ethylthio)griseofulvin (15) and 4'-(ethylthio)isogriseofulvin (16). The relationship between the ratios of isolated yield of 15 and 16 and antifungal the activity of griseofulvin derivatives is discussed.

• 公益社団法人日本薬学会の論文
• 1997-02-15

著者

• 竹内 洋文

  50周年誌編集小委員会

• Takeuchi Yoshikazu

  Lab. Of Clinical Pharmaceutics Fac. Of Pharmaceutical Sciences Kobe Gakuin Univ.

• 原山 尚

  Faculty Of Pharmaceutical Sciences Kyoto University

• Yamato M

  Okayama Univ. Science Okayama Jpn

• Yamato M

  Faculty Of Science Okayama University Of Science

• 竹内 豊

  Research Center Sumitomo Pharmaceuticals Co. Ltd.

• TAKEUCHI Yasuo

  Faculty of Pharmaceutical Sciences, Okayama University

• HARAYAMA Takashi

  Faculty of Pharmaceutical Sciences, Okayama University

• Takeuchi Y

  Faculty Of Pharmaceutical Sciences Okayama University

• Yamaoka Takashi

  Pharmacology Research Laboratories Dainippon Sumitomo Pharma Co. Ltd

• Takeuchi Y

  Research Center Sumitomo Pharmaceuticals Co. Ltd.

• Harayama Takashi

  Faculty Of Pharmaceutical Sciences Okayama University

• YAMATO Masatoshi

  Faculty of Pharmaceutical Sciences, Okayama University

• MISUMI Keiji

  Faculty of Pharmaceutical Sciences, Okayama University

• TOMOZANE Hideo

  Faculty of Pharmaceutical Sciences, Okayama University

• YATA Kuniko

  Faculty of Pharmaceutical Sciences, Okayama University

• KAWATA Teruyuki

  Faculty of Pharmaceutical Sciences, Okayama University

• NIINO Yoshiko

  Faculty of Pharmaceutical Sciences, Okayama University

• Yata Kuniko

  Faculty Of Pharmaceutical Sciences Okayama University

• Misumi Keiji

  Faculty Of Pharmaceutical Sciences Okayama University

• Niino Yoshiko

  Faculty Of Pharmaceutical Sciences Okayama University

• Tomozane H

  Faculty Of Pharmaceutical Sciences Okayama University

• Kawata T

  Faculty Of Pharmaceutical Sciences Okayama University

• Yamato Masatoshi

  Faculty Of Pharmaceutical Sciences Okayama University

• Takeuchi Yasuo

  Faculty Of Pharmaceutical Sciences Okayama University

• Harayama Takashi

  Faculty of Pharmaceutical Sciences at Kagawa Campus, Tokushima Bunri University

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