Skin Penetration Enhancing Action of cis-Unsaturated Fatty Acids with ω-9,and ω-12-Chain Lengths

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概要

• 論文の詳細を見る

• The skin penetrative action of high purity cis-ω-12-octadecenoic acid (petroselinic acid, HP-PSA) on rat skin was compared with that of high purity cis-ω-9-octadecenoic acid (oleic acid, HP-OA), following treatment of rat intact skin surface with either 0.05M HP-PSA or HP-OA in propylene glycol (PG), using Fourier transform/attenuated total reflection (FT-IR/ATR) analysis. Both HP-PSA and HP-OA disordered the lipid structures of the stratum corneum region to a similar extent. Removal of the extractable lipids of the stratum corneum region was marked with HP-PSA/PG but was very slight upon HP-OA/PG treatment. The spectra of the amide II region which originated from proteins suggests that HP-PSA/PG more rapidly disordered the protein structures of both the stratum corneum and the dermis than HP-OA/PG. However, the extent of disordering of the protein structures was presumed to be similar between these two skin penetration enhancers at the maximum level. Enhancement of PG flux in the dermis showed strong positive correlation with the degree of dermisdisordering action of HP-PSA/PG and HP-OA/PG. These results demonstrate that HP-PSA, which has a double bond at an even numbered position (ω-12), more rapidly affects the perturbation of the structures of both the stratum corneum and the dermis than HP-OA, which has the double bond at an odd numvered position (ω-9). Differences in the physicochemical properties of HP-PSA and HP-OA which originate from differences in the double bond position most likely determine the efficacy of these compounds as skin penetration enhancers.

• 社団法人日本薬学会の論文
• 1998-05-15

著者

• 竹内 洋文

  50周年誌編集小委員会

• 鈴木 益子

  仙台真菌研

• FUKUSHIMA Shoji

  Department of Pathology, Osaka City University Medical School

• Fukushima S

  Lab. Of Clinical Pharmaceutics Fac. Of Pharmaceutical Sciences Kobe Gakuin Univ.

• Takeuchi Yoshikazu

  Lab. Of Clinical Pharmaceutics Fac. Of Pharmaceutical Sciences Kobe Gakuin Univ.

• TAKEUCHI Yoshikazu

  Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Kobe Gakuin University

• MIYAWAKI Kohji

  Department of Pharmaceutics, Faculty of Pharmaceutical Science, Kobe Gakuin University

• YAMAOKA Yumiko

  Department of Pharmaceutics, Faculty of Pharmaceutical Science, Kobe Gakuin University

• TAGUCHI Kenji

  Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Kobe Gakuin University

• YASUKAWA Hidehito

  Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Kobe Gakuin University

• KISHIMOTO Syuichi

  Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Kobe Gakuin University

• SUZUKI Masao

  Olechemical Research Laboratory, NOF corporation

• 竹内 豊

  Research Center Sumitomo Pharmaceuticals Co. Ltd.

• 鈴木 恵

  Department Of Environmental Science Faculty Of Pharmaceutical Sciences Hokuriku University

• Takeuchi Yoshikazu

  Department Of Pharmaceutics Faculty Of Pharmaceutical Sciences Kobe Gakuin University

• Kishimoto Shuichi

  Department Of Pharmaceutics Faculty Of Pharmaceutical Sciences Kobegakuin University

• Kishimoto Shuichi

  Department Of Pharmaceutics Faculty Of Pharmaceutical Sciences Kobe Gakuin University

• Takeuchi Y

  Faculty Of Pharmaceutical Sciences Okayama University

• Miyawaki Kohji

  Department Of Pharmaceutics Faculty Of Pharmaceutical Science Kobe Gakuin University

• Yamaoka Takashi

  Pharmacology Research Laboratories Dainippon Sumitomo Pharma Co. Ltd

• Yasukawa Hidehito

  Department Of Pharmaceutics Faculty Of Pharmaceutical Sciences Kobe Gakuin University

• Takeuchi Y

  Research Center Sumitomo Pharmaceuticals Co. Ltd.

• Suzuki M

  Advanced Science And Technology Research Center Kyushu University

• Taguchi K

  Department Of Pharmacotherapeutics Showa Pharmaceutical University

• Yamaoka Y

  Kobe‐gakuin Univ. Kobe Jpn

• Yamaoka Yumiko

  Faculty Of Pharmaceutical Sciences And High-technology Research Center Kobe-gakuin University

• Fukushima Shoji

  Department Of Pathology Osaka City University Medical School

• Taguchi Kyoji

  Department Of Pharmacotherapeutics Showa Pharmaceutical University

• Yasukawa H

  Department Of Pharmaceutics Faculty Of Pharmaceutical Sciences Kobe Gakuin University

• Taguchi Kenji

  Department Of Applied Chemistry Nagoya Institute Of Technology

• Fukushima Shoji

  Department Of Gastroenterological Surgery Osaka City University Graduate School Of Medicine

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