Relation between Intracellular Accumulation and Cytotoxic Activity of cis-[((1Rl,2R)-l,2-Cyclohexanediamine-N,N')bis(myristato)]platinuni(II) Suspended in Lipiodol
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概要
- 論文の詳細を見る
SM-11355, cis-[((1R,2R)-l,2-cyclohexanediamine-N,N')bis(myristato)]platinum(II), suspended in Lipiodol (SM-11355/Lipiodol) showed cytotoxic activity in hepatic tumor models in vivo and tumor cell lines in vitro. SM-11355/Lipiodol demonstrated selective retention in tumor tissue in vivo and high accumulation in tumor cells in vitro. This study was aimed to clarify the relation between the cytotoxicity of SM-11355/Lipiodol and intracellular platinum content. The cytotoxic activities were estimated by using WST-1 reagent. Intracellular platinum content and platinum-DNA adduct were estimated following exposure with SM-11355/Lipiodol when methionine was added. Methionine clearly inhibited the cytotoxic activities of SM-11355/Lipiodol. Moreover, intracellular platinum content and platinum-DNA adduct following exposure of SM-11355/Lipiodol decreased with increases in methionine concentration. The characteristic release of SM-11355/Lipiodol was not affected by addition of methionine. The present results suggested that one of platinum compounds exposed to cells following SM-11355/Lipiodol treatment is very similar in cytotoxic mechanism to cisplatin.
- 社団法人日本薬学会の論文
- 2003-05-01
著者
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竹内 洋文
50周年誌編集小委員会
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FUKUSHIMA Shoji
Department of Pathology, Osaka City University Medical School
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Fukushima S
Lab. Of Clinical Pharmaceutics Fac. Of Pharmaceutical Sciences Kobe Gakuin Univ.
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Takeuchi Yoshikazu
Lab. Of Clinical Pharmaceutics Fac. Of Pharmaceutical Sciences Kobe Gakuin Univ.
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KISHIMOTO Shuichi
Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Kobe Gakuin University
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TAKEUCHI Yoshikazu
Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Kobe Gakuin University
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OHTANI Aya
Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Kobe Gakuin University
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FUKUDO Hisayuki
Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Kobe Gakuin University
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Fukudo Hisayuki
Department Of Pharmaceutics Faculty Of Pharmaceutical Sciences Kobe Gakuin University
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竹内 豊
Research Center Sumitomo Pharmaceuticals Co. Ltd.
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Takeuchi Yoshikazu
Department Of Pharmaceutics Faculty Of Pharmaceutical Sciences Kobe Gakuin University
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Kishimoto Shuichi
Department Of Pharmaceutics Faculty Of Pharmaceutical Sciences Kobegakuin University
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Kishimoto Shuichi
Department Of Pharmaceutics Faculty Of Pharmaceutical Sciences Kobe Gakuin University
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Takeuchi Y
Faculty Of Pharmaceutical Sciences Okayama University
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Ohtani Aya
Department Of Pharmaceutics Faculty Of Pharmaceutical Sciences Kobe Gakuin University
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Yamaoka Takashi
Pharmacology Research Laboratories Dainippon Sumitomo Pharma Co. Ltd
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Takeuchi Y
Research Center Sumitomo Pharmaceuticals Co. Ltd.
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Fukushima Shoji
Department Of Gastroenterological Surgery Osaka City University Graduate School Of Medicine
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Fukuda Hisayuki
Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Kobe Gakuin University
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