Preparation of and Drug Release from W/O/W Type Double Emulsions Containing Anticancer Agents Using an Oily Lymphographic Agent as an Oil Phase(Pharmaceutical)
スポンサーリンク
概要
- 論文の詳細を見る
W/O/W type double emulsions stable for a long time were prepared by two-step emulsifieation procedures using an oily lymphographic agent, Lipiodol Ultra-Fluid, and. a derivative of hydrogenated castor oil (HCO-10) as an oil phase. The yield of W/O/W type double emulsions was about 90%. Although the yield was not lowered by vigorous dispersion with a homogenizer, the size of oil droplets was decreased and the release rate of cytarabine was enhanced. Neither the concentration of cytarabine in, nor the volume of, the inner aqueous phase affected the release pattern of cytarabine from W/O/W type double emulsions. The release rate of 5-fluorouracil (5-FU) from the W/O/W type double emulsion was so fast that the release was completed within 1 h. The release of cytarabine and glucose was sustained and peplomycin was hardly released from the W/O/W type double emulsion. W/O type emulsions or W/O/W type double emulsions prepared in this study might be suitable as carriers of drugs such as peplomycin.
- 公益社団法人日本薬学会の論文
- 1987-08-25
著者
-
FUKUSHIMA Shoji
Department of Pathology, Osaka City University Medical School
-
NAKANO Masahiro
Department of Physics, Kyoto University
-
Nishida Mika
Department Of Pharmacy Kumamoto University Hospital
-
Fukushima Shoji
Faculty Of Pharmaceutical Sciences Kobe-gakuin University
-
Fukushima Shoji
Department Of Pharmacy Kumamoto University Hospital
-
Nakano Masahiro
Department Of Biologicalsciences Teikyo University Of Science And Technology
-
Fukushima Shoji
Department Of Pathology Osaka City University Medical School
-
Nakano Masahiro
Department Of Pharmacy Kumamoto University Hospital
-
Nakano Masahiro
Deparment Of Physics Kyushu University
-
Fukushima Shoji
Department Of Gastroenterological Surgery Osaka City University Graduate School Of Medicine
-
NAKANO MASAHIRO
Department of Pharmacy, Kumamoto University Hospital
関連論文
- T-Square Term of Electrical Resistivity : Condensed Matter and Statistical Physics
- Lack of a Dose-response Relationship for Carcinogenicity in the Rat Liver with Low Doses of 2-Amino-3,8-dimethylimidazo[4,5-f]quinoxaline or N-Nitrosodiethylamine
- Continuous Exposure to Low-Dose Cisplatin and Apoptosis(Miscellaneous)
- Relation between Intracellular Accumulation and Cytotoxic Activity of cis-[((1Rl,2R)-l,2-Cyclohexanediamine-N,N')bis(myristato)]platinuni(II) Suspended in Lipiodol
- Transdermal Drug Delivery by Electroporation Applied on the Stratum Corneum of Rat Using Stamp-Type Electrode and Frog-Type Electrode in Vitro
- Cytotoxicity of cis-[((1R,2R)-1,2-Cyclohexanediamine-N, N')bis(myristato)]-platinum (II) Suspended in Lipiodol in a Newly Established Cisplatin-resistant Rat Hepatoma Cell Line
- Use of Electroporation to Accelerate the Skin Permeability Enhancing Action of Oleic Acid
- In Vitro Release of SM-11355,cis[((1R, 2R)-1,2-Cyclohexanediamine-N, N')bis(myristato)]Platinum(II) Suspended in Lipiodol
- In Vitro Cytotoxicity of cis[((1R, 2R)-1,2-Cyclohexanediamine-N, N')bis(myristato)] platinum(II) Suspended in Lipiodol in Rat Hepatoma AH-109A Cells and Human Tumor Cell Lines
- Petroselinic Acid and Oleic Acid : Comparison of Enhanced Skin Permeability Relative to Affinity for Saturated Fatty Acids of Stratum Corneum
- Antitumor Effects of a Novel Lipophilic Platinum Complex (SM-11355) against a Slowly-Groing Rat Hepatic Tumor after Intra-Hepatic Arterial Administration
- Asclepic Acid(cis-ω7-Octadecenoic Acid) as a Skin Penetration Enhancer : Its Behavior and Effects on Rat Stratum Corneum and Dermis
- Enhancement of Propylene Glycol Distribution in the Skin by High Purity cis-Unsaturated Fatty Acids with Different Alkyl Chain Lengths Haiving Different Double Bond Position
- Skin Penetration Enhancing Action of cis-Unsaturated Fatty Acids with ω-9,and ω-12-Chain Lengths
- Enhancement of Propylene Glycol Permeation into Rat Dermis Using High-purity Oleic Acid and Subsequent Alteration of the Dermal Protein Structures
- Relation between Intracellular Accumulation and Cytotoxic Activity of cis-[((1Rl,2R)-l,2-Cyclohexanediamine-N,N')bis(myristato)]platinuni(II) Suspended in Lipiodol
- Cytotoxicity of cis-[((1R,2R)-1,2-Cyclohexanediamine-N, N')bis(myristato)]-platinum (II) Suspended in Lipiodol in a Newly Established Cisplatin-resistant Rat Hepatoma Cell Line
- In Vitro Release of SM-11355,cis[((1R, 2R)-1,2-Cyclohexanediamine-N, N')bis(myristato)]Platinum(II) Suspended in Lipiodol
- In Vitro Cytotoxicity of cis[((1R, 2R)-1,2-Cyclohexanediamine-N, N')bis(myristato)] platinum(II) Suspended in Lipiodol in Rat Hepatoma AH-109A Cells and Human Tumor Cell Lines
- Relation between Intracellular Accumulation and Cytotoxic Activity of cis-[((1Rl,2R)-l,2-Cyclohexanediamine-N,N')bis(myristato)]platinuni(II) Suspended in Lipiodol
- Cytotoxicity of cis-[((1R,2R)-1,2-Cyclohexanediamine-N, N')bis(myristato)]-platinum (II) Suspended in Lipiodol in a Newly Established Cisplatin-resistant Rat Hepatoma Cell Line
- In Vitro Release of SM-11355,cis[((1R, 2R)-1,2-Cyclohexanediamine-N, N')bis(myristato)]Platinum(II) Suspended in Lipiodol
- In Vitro Cytotoxicity of cis[((1R, 2R)-1,2-Cyclohexanediamine-N, N')bis(myristato)] platinum(II) Suspended in Lipiodol in Rat Hepatoma AH-109A Cells and Human Tumor Cell Lines
- Relation between Intracellular Accumulation and Cytotoxic Activity of cis-[((1Rl,2R)-l,2-Cyclohexanediamine-N,N')bis(myristato)]platinuni(II) Suspended in Lipiodol
- Cytotoxicity of cis-[((1R,2R)-1,2-Cyclohexanediamine-N, N')bis(myristato)]-platinum (II) Suspended in Lipiodol in a Newly Established Cisplatin-resistant Rat Hepatoma Cell Line
- In Vitro Release of SM-11355,cis[((1R, 2R)-1,2-Cyclohexanediamine-N, N')bis(myristato)]Platinum(II) Suspended in Lipiodol
- In Vitro Cytotoxicity of cis[((1R, 2R)-1,2-Cyclohexanediamine-N, N')bis(myristato)] platinum(II) Suspended in Lipiodol in Rat Hepatoma AH-109A Cells and Human Tumor Cell Lines
- Relation between Intracellular Accumulation and Cytotoxic Activity of cis-[((1Rl,2R)-l,2-Cyclohexanediamine-N,N')bis(myristato)]platinuni(II) Suspended in Lipiodol
- Cytotoxicity of cis-[((1R,2R)-1,2-Cyclohexanediamine-N, N')bis(myristato)]-platinum (II) Suspended in Lipiodol in a Newly Established Cisplatin-resistant Rat Hepatoma Cell Line
- In Vitro Release of SM-11355,cis[((1R, 2R)-1,2-Cyclohexanediamine-N, N')bis(myristato)]Platinum(II) Suspended in Lipiodol
- In Vitro Cytotoxicity of cis[((1R, 2R)-1,2-Cyclohexanediamine-N, N')bis(myristato)] platinum(II) Suspended in Lipiodol in Rat Hepatoma AH-109A Cells and Human Tumor Cell Lines
- Absence of β-catenin Mutations in Mouse Hepatoblastomas Induced by N,N-dimethylformamide
- Carcinogenic Potential of 2-Amino-3-methylimidazo[4,5-f]quinoline (IQ) in Severe Combined Immunodeficient (SCID) Mice
- Lack of Inhibition of BBN-induced Bladder Carcinogenesis in C57BL/6 Mice by Intravesical Instillation of KRN 7000
- P6-02 Enhancement of thioacetamide-induced liver cirrhosis by estradiol 3-benzoate in the rats(LIVER AND DIGESTIVE SYSTEM/CIRCULATORY SYSTEM-1/DEVELOPMENT AND REPRODUCTION)(GENERAL SESSION BY POSTER PRESENTATION)(Proceedings of the 31st Annual Meeting)
- Carcinogenicity of Dimethylarsinic Acid in F344 Rats and p53 (+/-) Knockout and Wild Type C57BL/6J Mice. Relevance with Genetic Alterations and Oxidative DNA Damage (CARCINOGENICITY) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th Annual
- Establishment and characterization of a human colonic mucinous carcinoma cell line with predominant goblet-cell differentiation from liver metastasis
- Existence of a no effect level for MeIQx hepatocarcinogenicity on a background of thioacetamide-induced liver damage in rats
- Differences in Sensitivity of F344 Rats from Different Breeders to Phenobarbital Hepatocarcinogenicity
- Differences in susceptibility to N-butyl-N-(4-hydroxybutyl)nitrosamine-induced urinary bladder carcinogenesis between SD/gShi rats with spontaneous hypospermatogenesis and SD/cShi rats with spontaneous hydronephrosis
- Histological and Mucin Histochemical Study of Colon Ulcers Induced in Rats by a Rapid Freezing Method
- Di-n-butyl Phthalate is Toxic to the Male Reproductive System and Its Toxicity is Enhanced by Thioacetamide Induced Liver Injury
- Food Restriction Inhibits the Growth of Intestinal Polyps in Multiple Intestinal Neoplasia Mouse
- Induction of DNA-adducts and increase of 8-hydroxy-2-deoxyguanosine, but no development of preneoplastic lesions in offspring liver with transplacental and trans-breast milk exposure to 2-amino-3, 8-dimethylimidazo [4, 5-f] quinoxaline (MeIQx) in rats
- Lack of Promoting Potential of Dimethylarsinic Acid in the Kidney of Male NCI-Black Reiter Rats
- p53 and H-ras Mutations and Microsatellite Instability in Renal Pelvic Carcinomas of NON/Shi Mice Treated with N-Butyl-N-(4-hydroxybutyl)-nitrosamine: Different Genetic Alteration from Urinary Bladder Carcinoma
- p53 in Multiple Human Urothelial Cancers: Assessment for Clonality by the Yeast p53 Functional Assay in Combination with p53 Immunohistochemistry
- Loss of Heterozygosity in (Lewis×F344)F_1 Rat Urinary Bladder Tumors Induced with N-Butyl-N-(4-hydroxybutyl) nitrosamine Followed by Dimethylarsinic Acid or Sodium L-Ascorbate
- Logistic Regression Analysis of Inherited Polymorphism as Modulators of Stomach Cancer
- Susceptibility of Four F_1 Hybrids of Male Rats to the Promoting Effects of Sodium L-ascorbate in Two-Stage Urinary Bladder Carcinogenesis
- Pharmacokinetics of Ephedrine and Pseudoephedrine after Oral Administration of Kakkonto to Healthy Male Volunteers
- Chemopreventive Effects of Bovine Lactoferrin on N-Butyl-N-(4-hydroxybutyl)nitrosamine-induced Rat Bladder Carcinogenesis
- RELATIVE BIOAVAILABILITY OF MIDAZOLAM FOLLOWING SUBLINGUAL VERSUS ORAL ADMINISTRATION IN HEALTHY VOLUNTEERS
- Ethanol Does Not Promote MeIQx-initiated Rat Colon Carcinogenesis Based on Evidence from Analysis of a Colon Cancer Surrogate Marker
- Upregulation of fibroblast growth factor receptor 3 and epidermal growth factor receptors, in association with Raf-1, in urothelial dysplasia and carcinoma in situ after the Chernobyl accident
- Hormesis in Carcinogenicity of Non-genotoxic Carcinogens
- Aberrant expression of E-cadherin and β-catenin in association with transforming growth factor-β1 in urinary bladder lesions in humans after the Chernobyl accident
- Dose-dependence of promotion of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline-induced rat hepatocarcinogenesis by ethanol : Evidence for a threshold
- Examination of the Rat Model of Liver Injury via Thioacetamide (TAA) or Carbon Tetrachloride (CCl_4)
- Significance of overexpression of metallothionein in mouse urinary bladder focal lesions induced by treatment with N-butyl-N-(4-hydroxybutyl)-nitrosamine
- Effect of Food on the Bioavailability of Bromazepam Following Oral Administration in Healthy Volunteers
- CLINICAL PHARMACOLOGICAL STUDIES OF ETHOTOIN IN PEDIATRIC EPILEPTIC PATIENTS
- New developments in INC model for medical application(Contribution to 21 Century Intelligent Technologies and Bioinformatics)
- Biphasic Increase of Epithelial DNA Synthesis in the Urinary Bladder of Rats Treated with a Tumor Promoter, Sodium L-ascorbate
- Experimental Study of the Relationship between Perfluoro-Octyl Bromide Emulsion and Norepinephrine Release in Reperfusion Arrhythmia : Isolated Guinea Pig Heart Model
- Urinary bladder lesions induced by persistent chronic low-dose ionizing radiation
- Lack of Inhibitory Effects of an Anti-angiogenesis Drug, TNP-470, on Rat Urinary Bladder Papillomatosis Induced by Mechanical Stimulation
- Development of a rapid assay for screening point mutations associated with quinolone resistance in the Pseudomonas aeruginosa parC gene
- Antimicrobial Activity of a New Fluoroquinolone, DU-6859a, against Quinolone-Resistant Clinical Isolates of Pseudomonas aeruginosa with Genetic Alterations in the GyrA Subunit of DNA Gyrase and the ParC Subunit of Topoisomerase IV
- Significance of Stenotrophomonas maltophilia in Urinary Tract Infections
- Comparison of urethral diameters for calculating the urethral dose after permanent prostate brachytherapy
- CT-based postimplant dosimetry of prostate brachytherapy : comparison of 1-mm and 5-mm section CT
- The potential role of prebiopsy magnetic resonance imaging combined with prostate-specific antigen density in the detection of prostate cancer
- Examination of Stability of Anticonvulsants in a Protease Solution and Assay of Anticonvulsants in Hairs
- Acyclothymidine Alleviates Intestinal Toxicity of 5'-Deoxy-5-fluorouridine without Loss of Antitumor Activity in Mice
- Modulation of the Pharmacokinetics of 5'-Deoxy-5-fluorouridine and 5-Fluorouracil in Rats by Oral Co-administration of Acyclothymidine
- Anticancer Activity of Free γ-Linolenic Acid on AH-109A Rat Hepatoma Cells and the Effect of Serum Albumin on Anticancer Activity of γ-Linolenic Acid in Vitro
- Hydrolysis of 3', 5'-Dioctanoyl-5-fluoro-2'-deoxyuridine (FdUrd-C8) in Rabbit and Human Plasma and Its Release from Oily Solution
- Bromocriptine Reverses P-Glycoprotein-mediated Multidrug Resistance in Tumor Cells
- High-performance liquid chromatographic assay for the simultaneous determination of lansoprazole enantiomers and metabolites in human liver microsomes
- Increase in Doxorubicin Cytotoxicity by Inhibition of P-glycoprotein Activity with Lomerizine
- Pharmacokinetic Differences between Lansoprazole Enantiomers and Contribution of Cytochrome P450 Isoforms to Enantioselective Metabolism of Lansoprazole in Dogs
- Inhibitory Effect of Human Immunodeficiency Virus Protease Inhibtors on Multidrug Resistance Transporter P-Glycoproteins
- Effect of Clarithromycin and Other Macrolides on the Sulfoxidation and 5-Hydroxylation of Lansoprazole in Dogs
- Inhibition of 5'-Deoxy-5-fluorouridine Phosphorolysis by Acyclothymidine in Tumor Cell Homogenates
- Effects of Betamipron on Cisplatin Nephrotoxicity and Its Pharmacokinetics in Rats
- Protective Effects of N-Benzoyl Amino Acids on Cisplatin Nephrotoxicity in Rats
- Urothelial Cancer Risk in Relation to Genotypes of Glutathione S-Transferase (GST) M1, T1, P1 and N-Acetyltransferase 2 (NAT2), and Tobacco Smoking
- Lack of Inhibitory Effects of Coumaperine from Pepper on the Promotion Stage of Chemical Hepatocarcinogenesis in the Rat
- Isolation of Differentiated Squamous and Undifferentiated Spindle Carcinoma Cell Lines with Differing Metastatic Potential from a 4-Nitroquinoline N-Oxide-induced Tongue Carcinoma in a F344 Rat
- Inhibitory effect of phenobarbital at low dose on rat hepatocarcinogenesis : the evidence for hormesis (CARCINOGENICITY) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th Annual Meeting)
- Thresholds for Carcinogenicity of Environmental Carcinogens (SYMPOSIUM3: RECENT TOPICS ON THE RISK ASSESSMENT OF CHEMICAL CARCINOGENS) (Proceedings of the 30th Annual Meeting)
- Application of liquid chromatography-tandem mass spectrometry for the determination of opioidmimetics in the brain dialysates from rats treated with opioidmimetics intraperitoneally
- Roles of Hydrophobicity, Protein Binding and the Probenecid-Sensitive Transport System in the Cerebrospinal Fluid Deliveryof Nucleoside Analogues with Anti-Viral Activity
- Lack of Enhanced Epithelial Cell Proliferation in the Urinary Bladder of Heterozygous p53 Knockout Mice Given Sodium Ortho-phenylphenate or Uracil
- Are tobacco use and urine pH indicated as risk factors for bladder carcinoma?
- PREPARATION AND EVALUATION OF W/O TYPE AND W/O/W TYPE EMULSIONS CONTAINING AN ANTICANCER DRUG
- S4-5 Analysis of Arsenic Carcinogenicity : Using Animal Models(SYMPOSIUM 4: ARSENIC IN THE ENVIRONMENT AND THE TOXICITY)(Proceedings of the 31st Annual Meeting)
- Experimental Studies on Artificial Blood Usage for Hemodilution during Cardiopulmonary Bypass
- Preparation of and Drug Release from W/O/W Type Double Emulsions Containing Anticancer Agents Using an Oily Lymphographic Agent as an Oil Phase(Pharmaceutical)