Protective Effects of N-Benzoyl Amino Acids on Cisplatin Nephrotoxicity in Rats
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概要
- 論文の詳細を見る
The protective effects of N-benzoyl amino acids (NAAs) and piperacillin (PIP), anionic transport inhibitors, against the nephrotoxicity of cisplatin were examined in rats. Male Wistar rats were injected i.p. with 6 mg/kg of cisplatin combined with i.p. NAAs or PIP. Rats were sacrificed on day 5 after cisplatin injection to weigh the kidney and liver, and to determine blood urea nitrogen (BUN) and serum creatinine (serum Cr) levels. Treatments with NAAs were an effective means of protection against cisplatin-induced nephrotoxicity. The combination of cisplatin with NAAs containing a short and straight chain significantly suppressed (p<0.05) the changes in body, kidney and liver weights, BUN and serum Cr. Further, betamipron (BP) at a 2000 mg/kg dose showed no apparent effect on the body, kidney and liver weights, BUN and serum Cr levels in rats. The combination of cisplatin with PIP caused a loss in body weight. The protective effects of PIP against cisplatin toxicity are inferior to those of BP when compared at 250 mg/kg doses.
- 公益社団法人日本薬学会の論文
- 1996-11-15
著者
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KITAGAWA Akira
Department of Clinical Trial Management, Graduate School, International University of Health and Wel
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NAKANO Masahiro
Department of Physics, Kyoto University
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Nakano M
Department Of Information Science University Of Occupational And Environmental Health
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TOKUNAGA Jin
Department Pharmacy, Kumamoto University Hospital
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NAKAMURA Chizuko
Department of Pharmacy, Kumamoto University Hospital
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ARIMORI Kazuhiko
Department of Pharmacy, Miyazaki Medical College Hospital
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KOBAYASHI Mie
Department of Pharmaceutical Services, Kumamoto University Hospital
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Nakano M
University Of Occupational And Environmental Health
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Nakano M
Department Of Biologicalsciences Teikyo University Of Science And Technology
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Nakano Masahiro
Department Of Biologicalsciences Teikyo University Of Science And Technology
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Kobayashi M
Department Of Analytical Chemistry Faculty Of Pharmaceutical Sciences Josai University
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Kobayashi Mie
Department Of Pediatric Dentistry Osaka Dental University
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Kitagawa Akira
Department Of Clinical Trial Management Graduate School International University Of Health And Welfa
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Kitagawa Akira
Department Of Pharmaceutical Services Kumamoto University Hospital
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Nakano M
Univ. Occupational And Environmental Health Jpn
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Nakamura Chizuko
Department Of Pharmacy Kumamoto University Hospital
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Arimori K
Department Of Pharmacy Miyazaki Medical College Hospital
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Arimori Kazuhiko
Department Of Pharmacy Kumamoto University Hospital
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Nakano Masahiro
Deparment Of Physics Kyushu University
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Arimori Kazuhiko
Department Of Pharmacy Faculty Of Medicine University Of Miyazaki
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