Inhibitory Effects of Fruit Juices on Cytochrome P450 2C9 Activity in Vitro
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概要
- 論文の詳細を見る
There is limited information on the effect of fruits on human cytochrome P450 (CYP) 2C9 activity. The objective of this study was to determine the effect of fruit juice on CYP2C9-mediated drug metabolism. Nine citrus fruits and eight tropical fruits were chosen. We investigated effects of the fruits on diclofenac 4′-hydroxylation and tolbutamide hydroxylation by human liver microsomes. Among the fruits, pineapple juice showed potent inhibition of CYP2C9 activity. The addition of 25 μl (5.0% v/v) of pineapple juice resulted in almost complete inhibition. Next we examined the inhibitory effect of bromelain, a cysteine protease in pineapple. Bromelain also strongly inhibited CYP2C9 activity. In addition, E-64, a cysteine protease inhibitor, almost entirely blocked inhibition by pineapple juice and bromelain. Thus we found that pineapple juice was a potent inhibitor of CYP2C9, and that the inhibitory effect might be due to the bromelain contained in pineapple.
- 社団法人 日本農芸化学会の論文
- 2008-02-23
著者
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KAI Hirofumi
Department of Molecular Medicine, Graduate School of Pharmaceutical Sciences, Global COE Cell Fate R
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SEKIYA Hiroshi
Department of Molecular Microbiology, Graduate School of Medicine, Dentistry and Pharmaceutical Scie
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Kai Hirofumi
Dep. Of Molecular Medicine Fac. Of Medical And Pharmaceutical Sciences Kumamoto Univ.
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Okumura Manabu
Department Of Pharmacy Miyazaki Medical College Hospital
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Okumura Manabu
Tokyo Institute Of Technology Precision And Intelligence Laboratory
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Okumura Manabu
Department Of Computer Science Japan Advanced Institute Of Science And Technology
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ARIMORI Kazuhiko
Department of Pharmacy, Miyazaki Medical College Hospital
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Sekiya Hiroshi
Department Of Chemistry Faculty Of Sciences Kyushu University
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Okumura M
Dep. Of Pharmacy Univ. Of Miyazaki Hospital
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Hidaka Muneaki
Department Of Pharmacy Miyazaki Medical College Hospital
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Nagata Masashi
School Of Pharmaceutical Sciences Kyushu University Of Health And Welfare:department Of Pharmacy Fac
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Kai Hirofumi
Department Of Molecular Medicine Faculty Of Pharmaceutical Sciences Kumamoto University
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Kawano Yohei
Department Of Pharmacy Faculty Of Medicine University Of Miyazaki Hospital
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Kawano Yohei
Department Of Immune Regulation Tokyo Medical And Dental University Graduate School
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YAMASAKI Keishi
Department of Pharmacy, Miyazaki Medical College Hospital
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Yamasaki Keishi
Dep. Of Pharmacy Univ. Of Miyazaki Hospital
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HIDAKA Muneaki
School of Pharmaceutical Sciences, Kyushu University of Health and Welfare
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Yamasaki Keishi
Department Of Pharmacy University Of Miyazaki Hospital
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Sekiya Hiroshi
Department Of Pharmacy University Of Miyazaki Hospital
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Nagata Masashi
School Of Pharmaceutical Sciences Kyushu University Of Health And Welfare
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Sekiya Hiroshi
Department Of Chemistry And Physics Graduate School Of Sciences Kyushu University
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Arimori Kazuhiko
Department Of Pharmacy Miyazaki Medical College Hospital
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Arimori Kazuhiko
Department Of Pharmacy Kumamoto University Hospital
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Arimori Kazuhiko
Department Of Pharmacy Faculty Of Medicine University Of Miyazaki
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