Mild Electrical Stimulation Increases Ubiquitinated Proteins and Hsp72 in A549 Cells via Attenuation of Proteasomal Degradation
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概要
- 論文の詳細を見る
To explore the cellular effects of mild electrical stimulation (MES), we treated A549 cells with low-intensity direct current at 5 V applied for 10 min. MES did not induce cell cytotoxicity or the unfolded protein response (UPR). Interestingly, the expression of ubiquitinated proteins and heat shock protein (Hsp) 72 was increased but not that of other Hsps. MES attenuated the degradation of Hsp72, which is a substrate of the proteasome-ubiquitin system. These results, along with the observed increase in expression of ubiquitinated proteins, imply that MES may affect the proteasome system, which regulates the fate of many proteins.
- 社団法人 日本薬理学会の論文
- 2008-10-20
著者
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SUICO Mary
Department of Molecular Medicine, Graduate School of Pharmaceutical Sciences, Global COE Cell Fate R
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SHUTO Tsuyoshi
Department of Molecular Medicine, Graduate School of Pharmaceutical Sciences, Global COE Cell Fate R
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KAI Hirofumi
Department of Molecular Medicine, Graduate School of Pharmaceutical Sciences, Global COE Cell Fate R
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Yano Shuichiro
Department of Molecular Medicine, Graduate School of Pharmaceutical Sciences, Global COE “Cell Fate
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Kondo Tatsuya
Department of Metabolic Medicine, Faculty of Life Sciences, Kumamoto University, Japan
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Araki Eiichi
Department of Metabolic Medicine, Faculty of Life Sciences, Kumamoto University, Japan
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Suico Mary
Department Of Molecular Medicine Graduate School Of Pharmaceutical Sciences Global Coe Cell Fate Reg
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Kai Hirofumi
Department Of Molecular Medicine Graduate School Of Pharmaceutical Sciences Global Coe Cell Fate Reg
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Matsuda Tomoko
Department Of Physiology Gifu University School Of Medicine
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Matsuda Tomoko
Dep. Of Clinical Pharmacology Fac. Of Medical Sciences Kyushu Univ. Jpn
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Matsuda Tomoko
Department Of Materials Chemistry Ryukoku University
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Shuto Tsuyoshi
Department Of Molecular Medicine Graduate School Of Pharmaceutical Sciences Global Coe Cell Fate Reg
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Araki Eiichi
Department Of Metabolic Medicine Faculty Of Medical And Pharmaceutical Sciences Kumamoto University
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Yano Shuichiro
Department Of Biological Science Graduate School Of Science Hiroshima University
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Kondo Tatsuya
Department Of Developmental Genetics Kumamoto University
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MORINO Saori
Department of Molecular Medicine, Graduate School of Pharmaceutical Sciences, Global COE "Cell Fate
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SEKIMOTO Erika
Department of Molecular Medicine, Graduate School of Pharmaceutical Sciences, Global COE "Cell Fate
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MATSUNO Takashi
Department of Molecular Medicine, Graduate School of Pharmaceutical Sciences, Global COE "Cell Fate
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Sekimoto Erika
Department Of Molecular Medicine Graduate School Of Pharmaceutical Sciences Global Coe "cell Fa
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Kai Hirofumi
Department Of Molecular Medicine Faculty Of Pharmaceutical Sciences Kumamoto University
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Matsuno Takashi
Department Of Mechanical And Aerospace Engineering Tottori University
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Matsuno Takashi
Department Of Molecular Medicine Graduate School Of Pharmaceutical Sciences Global Coe "cell Fa
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Matsuda Tomoko
Department Of Clinical Pharmacology Faculty Of Medical Sciences Kyushu University
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Matsuda Tomoko
Department Of Bioengineering Tokyo Institute Of Technology
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Araki Eiichi
Department Of Metabolic Medicine Faculty Of Life Sciences Kumamoto University
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Suico Mary
Department Of Molecular Medicine Graduate School Of Pharmaceutical Sciences Global Coe "cell Fa
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Shuto Tsuyoshi
Department Of Molecular Medicine Graduate School Of Pharmaceutical Sciences Global Coe "cell Fa
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Yano Shuichiro
Department Of Molecular Medicine Graduate School Of Pharmaceutical Sciences Global Coe "cell Fa
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Morino-koga Saori
Dep. Of Molecular Medicine Graduate School Of Pharmaceutical Sciences Global Coe “cell Fate Regulation Res. And ...
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