The Regulation of Human .BETA.-Defensin 2 by the ETS Transcription Factor MEF (Myeloid Elf-1-Like Factor) Is Enhanced by Promyelocytic Leukemia Protein
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概要
- 論文の詳細を見る
The human β-defensin 2 (HBD 2) is a potent anti-bacterial peptide with a wide spectrum of activity. MEF (myeloid elf-1-like factor) or Elf4, a member of the ETS transcription factor family, has been shown to up-regulate the basal expression of the HBD 2 gene in epithelial cells. The mammalian cell nucleus is organized into distinct nuclear domains, one of which is the PML (promyelocytic leukemia) nuclear body involved in the regulation of transcription. Here, we show that PML stimulated MEF transcriptional activity, resulting in the up-regulation of endogenous HBD 2 expression.
- 公益社団法人 日本薬理学会の論文
著者
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Li Jian-dong
Gonda Department Of Cell And Molecular Biology
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Koga Tomoaki
Department Of Molecular Medicine Graduate School Of Pharmaceutical Sciences Global Coe Cell Fate Reg
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Yoshida Hiroki
Department Of Biomolecular Sciences Faculty Of Medicine Saga University
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Lu Zhuo
Department Of Molecular Medicine Faculty Of Medical And Pharmaceutical Sciences Kumamoto University
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Uchikawa Tomoko
Department Of Molecular Medicine Faculty Of Medical And Pharmaceutical Sciences Kumamoto University
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Nakao Mitsuyoshi
Department Of Regeneration Medicine Institute Of Molecular Embryology And Genetics Graduate School O
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Kai Hirofumi
Department Of Molecular Medicine Faculty Of Pharmaceutical Sciences Kumamoto University
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Matsuzaki Kazuhito
Department Of Neurosurgery Kawasaki Medical School
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Suico Mary
Department Of Molecular Medicine Graduate School Of Pharmaceutical Sciences Global Coe "cell Fa
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Shuto Tsuyoshi
Department Of Molecular Medicine Graduate School Of Pharmaceutical Sciences Global Coe "cell Fa
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LI Jian-Dong
Gonda Department of Cell and Molecular Biology, House Ear Institute, University of Southern California
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YOSHIDA Hiroki
Department of Molecular Medicine, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University
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Kai Hirofumi
Department of Molecular Medicine, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University
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Suico Mary
Department of Molecular Medicine, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University
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Koga Tomoaki
Department of Molecular Medicine, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University
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YOSHIDA Hiroki
Department of Biochemistry, Microbiology, and Clinical Pharmacy, Graduate School of Clinical Pharmacy, Kyushu University of Health and Welfare
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