Effects of Exposure Period and Dose of Diethylstilbestrol on Pregnancy in Rats

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概要

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• The aim of this study was to investigate the effect of exposure period and dose of diethylstilbestrol (DES), which has strong estrogenic activity, on pregnancy in rats. All rats with observed vaginal plugs or sperm in vaginal smear tests after mating were divided into 3 groups: those fed a normal diet, a diet mixed with DES throughout pregnancy and a diet mixed with DES from day 13 of pregnancy. DES was mixed into the diet at 0.1, 1, 10 and 100 ppm. All bred rats fed the normal diet and 0.1 ppm DES from day 13 of pregnancy delivered pups, while none of the rats treated with 1-100 ppm DES during pregnancy and 100 ppm DES from day 13 of pregnancy delivered any pups. The number of male and female pups born decreased in rats treated with 10 ppm DES from day 13 of pregnancy. These results suggest that DES could affect pregnancy and that the exposure period and dose may result in sterility, abortion, poor fetal growth and reduced number of pups born.

• 社団法人　日本獣医学会の論文

著者

• Miyoshi Noriaki

  Department of Veterinary Pathology, Faculty of Agriculture, Kagoshima University, Japan

• Miura Naoki

  Department Of Veterinary Medicine Faculty Of Agriculture Kagoshima University

• Yoshida Hiroki

  Department Of Biomolecular Sciences Faculty Of Medicine Saga University

• YASUDA Nobuhiro

  Department of Chemistry and Materials Science, Tokyo Institute of Technology

• Kawaguchi Hiroaki

  Department Of Inf. Science Shonan Institute Of Technology

• Souda Masakazu

  Department Of Tumor Pathology Field Of Oncology Kagoshima University Graduate School Of Medical And

• MIYAMOTO Yoko

  Department of Information and Communication Engineering, The University of Electro-Communications

• Umekita Yoshihisa

  Department Of Pathology Faculty Of Medicine Kagoshima University

• Miyoshi Noriaki

  Dep. Of Veterinary Pathology Fac. Of Agriculture Kagoshima Univ. Jpn

• Miyamoto Yoko

  Department Of Information And Communication Engineering The University Of Electro-communications

• Kawaguchi Hiroaki

  Department Of Veterinary Experimental Animal Science Faculty Of Agriculture Kagoshima University

• Miyoshi Noriaki

  Department Of Veterinary Pathology Faculty Of Agriculture Kagoshima University

• Hirakawa Kimiaki

  鹿児島大学 農学部実験動物学

• YOSHIDA Hiroki

  Department of Biochemistry, Microbiology, and Clinical Pharmacy, Graduate School of Clinical Pharmacy, Kyushu University of Health and Welfare

• SOUDA Masakazu

  Department of Tumor Pathology, Field of Oncology, Graduate School of Medical and Dental Sciences, Kagoshima University

• MIYAMOTO Yoko

  Department of Engineering Science, The University of Electro-Communications

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