Microminipig, a Non-rodent Experimental Animal Optimized for Life Science Research:Novel Atherosclerosis Model Induced by High Fat and Cholesterol Diet

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概要

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• Atherosclerotic lesions were observed in male and ovariectomized female Microminipig (MMP) fed a high fat and cholesterol diet with sodium cholate (HFCD/SC) for 3 months. HFCD/SC induced hypercholesterolemia accompanied by an increase in serum total cholesterol (T-Cho), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and cholesterol ester (CE). Unlike the mouse or rabbit, a dominant LDL-C fraction in the intact MMP, similar to that in humans, was observed by serum lipoprotein analysis. HFCD/SC increased body weight gain. At the end of the experiment, computed tomography scans of conscious animals showed that HFCD/SC had decreased liver attenuation values (Hounsfield unit) and increased subcutaneous and abdominal fat, suggesting the induction of fatty liver and obesity. HFCD/SC induced atherosclerotic lesions in systemic arteries, including the external and internal iliac arteries, abdominal aorta, coronary artery, and cerebral arterial circle. Atherosclerosis and pathological findings induced by HFCD/SC in MMP were similar to those in humans. The MMP is a potentially suitable tool for investigating human atherosclerosis.

著者

• NAGATA Ryoichi

  Shin Nippon Biomedical Laboratories (SNBL), Ltd.

• IZUMI Yasukatsu

  Department of Pharmacology, Osaka City University Medical School

• Kawaguchi Hiroaki

  Department of Veterinary Experimental Animal Science, Faculty of Agriculture, Kagoshima University,

• Miyoshi Noriaki

  Department of Veterinary Pathology, Faculty of Agriculture, Kagoshima University, Japan

• Miura Naoki

  Veterinary Teaching Hospital, Faculty of Agriculture, Kagoshima University, Japan

• Fujiki Makoto

  Department of Surgery, Faculty of Agriculture, Kagoshima University, Japan

• Horiuchi Masahisa

  Department of Environmental Medicine, Kagoshima University Graduate School of Medical and Dental Sci

• Miyajima Hiroaki

  Shin Nippon Biomedical Laboratories, Ltd., Japan

• Misumi Kazuhiro

  Department of Surgery, Faculty of Agriculture, Kagoshima University, Japan

• Takeuchi Toru

  Department of Environmental Medicine, Kagoshima University Graduate School of Medical and Dental Sci

• Tanimoto Akihide

  Department of Molecular and Cellular Pathology, Kagoshima University Graduate School of Medical and

• Yoshida Hiroki

  President, Kagoshima University, Japan

• Miura Naoki

  Department Of Veterinary Medicine Faculty Of Agriculture Kagoshima University

• Nagata Ryoichi

  Shin Nippon Biomedical Laboratories (snbl) Ltd.

• Miyajima Hiroaki

  Shin Nippon Biochemical Laboratories Ltd.

• Kawaguchi Hiroaki

  Department Of Inf. Science Shonan Institute Of Technology

• Horiuchi Masahisa

  Department Of Biochemistry Faculty Of Medicine Kagoshima University

• Takeuchi Toru

  Department Of Environmental Medicine Faculty Of Medicine Kagoshima University

• Izumi Yasukatsu

  Department Of Pharmacology Osaka City University Graduate School Of Medicine

• Miyoshi Noriaki

  Dep. Of Veterinary Pathology Fac. Of Agriculture Kagoshima Univ. Jpn

• Yoshida Hiroki

  President Kagoshima Univ. Jpn

• Nagata Ryoichi

  Shin Nippon Biomedical Lab. Ltd.

• Misumi Kazuhiro

  Department Of Surgery Faculty Of Agriculture Kagoshima University

• Kawaguchi Hiroaki

  Department Of Veterinary Experimental Animal Science Faculty Of Agriculture Kagoshima University

• Miyoshi Noriaki

  Department Of Veterinary Pathology Faculty Of Agriculture Kagoshima University

• Fujiki Makoto

  Department Of Surgery Faculty Of Agriculture Kagoshima University

• Tanimoto Akihide

  Department Of Molecular And Cellular Pathology Kagoshima University Graduate School Of Medical And D

• Miura Naoki

  Veterinary Teaching Hospital Faculty Of Agriculture Kagoshima University

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