Immunohistochemical Detection of Proteins Associated with Multidrug Resistance to Anti-Cancer Drugs in Canine and Feline Primary Pulmonary Carcinoma

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概要

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• Fifty-two canine and eighteen feline primary pulmonary carcinomas were evaluated immunohistochemically for the expression of proteins associated with multidrug resistance to anti-cancer drugs. P-glycoprotein (PGP), multidrug resistance-related protein (MRP) and lung resistance-related protein (LRP) expression were frequently observed in neoplastic cells of all carcinoma types, and metallothionein (MT) expression was observed in about half of each carcinoma type. Furthermore, overlapping expression was detected in all positive cases. These results indicate that most canine and feline primary pulmonary carcinomas may have strong multidrug resistance, which is related to the PGP, MRP, LRP or MT expression. It might be difficult to treat canine and feline primary pulmonary carcinomas using anti-cancer drugs because of multidrug resistance.

• 社団法人　日本獣医学会の論文

著者

• Miyoshi Noriaki

  Department of Veterinary Pathology, Faculty of Agriculture, Kagoshima University, Japan

• Miura Naoki

  Department Of Veterinary Medicine Faculty Of Agriculture Kagoshima University

• YASUDA Nobuhiro

  Department of Chemistry and Materials Science, Tokyo Institute of Technology

• NOMURA Kohji

  Marupi Lifetech Co., Ltd.

• Kawaguchi Hiroaki

  Department Of Inf. Science Shonan Institute Of Technology

• Miyoshi Noriaki

  Dep. Of Veterinary Pathology Fac. Of Agriculture Kagoshima Univ. Jpn

• HIFUMI Tatsuro

  Department of Veterinary Pathology, Faculty of Agriculture, Kagoshima University

• Miyoshi Noriaki

  Department Of Veterinary Pathology Faculty Of Agriculture Kagoshima University

• Hirakawa Kimiaki

  鹿児島大学 農学部実験動物学

• Miyoshi Noriaki

  Dep. Of Veterinary Histopathology Joint Fac. Of Veterinary Medicine Kagoshima Univ.

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