The Effects of Medetomidine on Maternal and Fetal Cardiovascular and Pulmonary Function, Intrauterine Pressure and Uterine Blood Flow in Pregnant Goats
スポンサーリンク
概要
- 論文の詳細を見る
To investigate the effects of medetomidine on late pregnant goats, medetomidine induced changes in maternal or fetal circulation and acid-base balance, as well as changes in intrauterine pressure (IUP) and uterine blood flow (UBF), were studied. Intramuscular administration of medetomidine (40 μg/kg b.w.) decreased the heart rate (HR) and arterial blood pressure (ABP) of the mother, and the change in HR was significant statistically (p<0.05). In the fetus, HR and ABP showed a transient decrease and increase (p<0.05), respectively. A decrease in maternal arterial blood pH and oxygen partial pressure (PO2) and an increase in carbon dioxide partial pressure (PCO2) were recorded after the injection, but none was significant. In the fetus, arterial blood PO2 decreased significantly (p<0.05) after 5 min of administration, and a significant metabolic acidemia supported by a decrease in base excess was observed. Within 1 to 4 min after the administration of medetomidine, IUP began to rise and remained high for 10 to 14 min. Thereafter, the rise in IUP was frequent and periodical. After the injection, UBF significantly (p<0.05) decreased, and the fall in UBF was associated with a rise in IUP. The maternal and fetal serum medetomidine concentration increased remarkably after the injection of medetomidine into the mother. These observations in late pregnant goats suggested that medetomidine induced a decrease in maternal cardiac output, a decrease in UBF arising from the induction of uterine contractions, and transplacental medetomidine can have a suppressive effect on the fetus.
- 社団法人 日本実験動物学会の論文
著者
-
Misumi K
The Laboratory Of Veterinary Surgery Department Of Veterinary Medicine Faculty Of Agriculture Kagosh
-
Miura Naoki
Department Of Veterinary Medicine Faculty Of Agriculture Kagoshima University
-
Fujiki Makoto
Department Of Veterinary Surgery Kagoshima University
-
Sakamoto H
The Laboratory Of Veterinary Surgery Department Of Veterinary Medicine Faculty Of Agriculture Kagosh
-
MISUMI Kazuhiro
Laboratory of Veterinary Surgery, Department of Veterinary Medicine, Faculty of Agriculture, Kagoshi
-
Kirihara Hidetoshi
Laboratory Of Veterinary Surgery Department Of Veterinary Medicine Faculty Of Agriculture Kagoshima
-
SAKAMOTO HIROSHI
Laboratory of Veterinary Surgery, Department of Veterinary Medicine, Facuty of Agriculture, Kagoshim
-
Misumi Kazuhiro
Department Of Veterinary Surgery Faculty Of Agriculture Kagoshima University
-
Misumi Kazuhiro
Laboratory Of Veterinary Surgery Department Of Veterinary Medicine Faculty Of Agriculture Kagoshima
-
MIURA Naoki
Laboratory of Veterinary Surgery, Department of Veterinary Medicine, Faculty of Agriculture, Kagoshi
-
FUJIKI Makoto
Laboratory of Veterinary Surgery, Department of Veterinary Medicine, Faculty of Agriculture, Kagoshi
-
Fujiki Makoto
Laboratory Of Veterinary Surgery Department Of Veterinary Medicine Faculty Of Agriculture Kagoshima
-
Miyoshi Noriaki
Dep. Of Veterinary Pathology Fac. Of Agriculture Kagoshima Univ. Jpn
-
Sakamoto H
Laboratory Of Veterinary Surgery Department Of Veterinary Medicine Faculty Of Agriculture Kagoshima
-
Sakamoto Hiroshi
Laboratory Of Biochemistry Department Of Chemistry Faculty Of Science Kyushu University
-
FUJIKI Makoto
Laboratory of Surgery, Joint Faculty of Veterinary Medicine, Kagoshima University, 1–21–24 Korimoto, Kagoshima 890–0065, Japan
-
MIURA Naoki
Laboratory of Veterinary Diagnostic Imaging, Department of Veterinary Medicine, Joint Faculty of Veterinary Medicine, Kagoshima University, 1–21–24 Korimoto, Kagoshima 890–0065, Japan
-
FUJIKI Makoto
Laboratory of Surgery, Joint Faculty of Veterinary Medicine, Kagoshima University
関連論文
- Microminipig, a Non-rodent Experimental Animal Optimized for Life Science Research:Novel Atherosclerosis Model Induced by High Fat and Cholesterol Diet
- EFFECT OF IABP TO HEMODYNAMICS IN AORTIC REGURGITATION : EXPERIMENTAL STUDY : Extracorporeal Circulation, Aortic Aneurysm : 53 Annual Scientific Meeting, Japanese Circulation Society
- ATP Sensitive Concealed Accessory Pathway without Rate-dependent Prolongation of Ventriculo-atrial Conduction in Atrioventricular Reciprocating Tachycardia : An Unusual Response and its Possible Mechanism
- Fourteen-Year Survival in a Case of Ventricular Septal Perforation after Myocardial Infarction
- Discrepancy between Doppler and Catheter Measurements of Pressure Gradients across Small-size Prosthetic Valve
- Assessment of Optimal Atrioventricular Delay Using Doppler Index in Atrioventricular Sequential Pacing
- Sudden Death during Holter Electrocardiogram Monitoring in a Patient with Variant Angina
- Chaotic Musical Murmur in Aortic Regurgitation
- Smooth Muscle Cell Proliferation in the Arterial Intima after Stretch Injury: Relationship between the Severity of Stretching and Intime Hyperplasia in New Zealand White Rabbits
- MYOCARDIAL INFARCTION INDUCED BY CORONARY VENOUS THROMBOSIS : An Experimental Study
- The Hemodynamic Effects of Acute Myocardial Ischemia and Reperfusion in Clawn Miniature Pigs
- Salt Water Promotes Hypertension in Dahl-S Rats
- Branching Patterns in Coronary Artery and Ischemic Areas Induced by Coronary Arterial Occlusion in the CLAWN Miniature Pig
- Fine Structure of the Parotid Gland in Tree Shrew (Tupaia glis)
- EXPERIMENTAL STUDY OF ACUTE CORONARY SINUS THROMBOSIS : Clinical References to Coronary Sinus Thrombosis and Coronary Venography
- Short-term effect of American summer treatment program for Japanese children with attention deficit hyperactivity disorder
- Phosphorylation Influences The Association of p53 Tetramers
- Inactivation of Gramicidin S by Acylation of Two Ornithine Residues with Higher Fatty Acids
- Development of Atherosclerotic Lesions in Cholesterol-loaded Rabbits
- The Effects of Medetomidine on Maternal and Fetal Cardiovascular and Pulmonary Function, Intrauterine Pressure and Uterine Blood Flow in Pregnant Goats
- Ependymoblastoma in a Japanese Black Heifer
- Relationship between Arterial and End-Tidal Carbon Dioxide Pressure during Controlled Ventilation in Porcine Neonates
- Effects of a Calcium Antagonist(Nicardipine) on Cardiovascular Function in Goats
- Effects of Olprinone on Myocardial Ischemia-Reperfusion Injury in Dogs
- New preoperative evaluation system of the physical findings of aged patients with femoral neck fracture
- Smooth Muscle Cell Proliferation in the Arterial Intima after Stretch Injury: Relationship between the Severity of Stretching and Intima Hyperplasia in New Zealand White Rabbits
- Immunohistochemical Detection of Proteins Associated with Multidrug Resistance to Anti-Cancer Drugs in Canine and Feline Primary Pulmonary Carcinoma
- Effects of Fetal Exposure to Diethylstilbestrol on Mammary Tumorigenesis in Rats
- Effects of Exposure Period and Dose of Diethylstilbestrol on Pregnancy in Rats
- Detection of antibodies against Fusobacterium necrophorum and Porphyromonas levii-like species in dairy cattle with papillomatous digital dermatitis
- Effect of habitual exercise on renal carcinogenesis by ferric nitrilotriacetate
- Microminipig, a Non-rodent Experimental Animal Optimized for Life Science Research : Novel Atherosclerosis Model Induced by High Fat and Cholesterol Diet
- CT and MRI Imaging Diagnosis of Epidural Idiopathic Sterile Pyogranulomatous Inflammation in a Dog Spinal Canal
- Abnormal Erythroid Cell Proliferation and Myelofibrosis in a Cat
- Cross-Reactivity of the Anti-Human D-Dimer Monoclonal Antibody 1C9-6F10 to Canine Fibrin Degradation Products
- Opioid activities of morphiceptin analogs derived from human .BETA.-casein.
- Generalized Alopecia with Vasculitis-Like Changes in a Dog with Babesiosis
- Dipeptide Side Chain-Side Chain Hydrophobic Interactions as Conformational Core for Chymotrypsin Inhibition.
- Molecular Cloning of Canine nm23 cDNAs and Their Expression in Normal and Tumor Tissues
- Tensile Force of Pacing Lead Extraction. A Comparison between Tined Type and Screw-in Type.:A Comparison between Tined Type and Screw-in Type
- Ganglion Cysts Arising from a Canine Stifle Joint
- Effects of Milrinone on Hemodynamics and Regional Blood Flow in the Hypoxic Dog.
- α,β-Unsaturated Carboxylic Acid Derivatives. X. The Synthesis and Reaction of α-Azido-diethoxyphosphinyl-α- and β-alkenes