Smooth Muscle Cell Proliferation in the Arterial Intima after Stretch Injury: Relationship between the Severity of Stretching and Intima Hyperplasia in New Zealand White Rabbits
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概要
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We examined histologically whether the severity of arterial stretch injury is related to the degree of subsequent intimal hyperplasia. In six male New Zealand White rabbits, the common carotid artery was hyperextended with a 3F Fogarty balloon catheter. Two weeks later, no proliferative change was evident in the intima in the most hyperextended portion. Paradoxically, however, intimal hyperplasia due to smooth muscle cell proliferation was observed in the moderately extended portions. The intimal hyperplasia appeared to be exacerbated where the arterial stretching was more severe. It is concluded that the severity of arterial stretch injury is closely related to the intimal proliferation of smooth muscle cells.
著者
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NOZAKI Shusaku
Laboratory of Veterinary Surgery, Department of Veterinary Medicine, Faculty of Agriculture, Kagoshi
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KUROSE Mitsuro
Shinkyo Hospital
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SOHARA Hiroshi
Shinkyo Hospital
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AMITANI Shigeru
Shinkyo Hospital
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Misumi Kazuhiro
Laboratory Of Veterinary Surgery Department Of Veterinary Medicine Faculty Of Agriculture Kagoshima
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Sakamoto Hiroshi
Laboratory Of Biochemistry Department Of Chemistry Faculty Of Science Kyushu University
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MIYAHARA Kenkichi
Shinkyo Hospital
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