Molecular Cloning of Canine nm23 cDNAs and Their Expression in Normal and Tumor Tissues
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概要
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Two canine nm-23 cDNAs, designated as nm23-C1 and -C2, were isolated and characterized. Both have a putative open reading frame consisting of 459-bp encoding 152 amino acids and are highly similar to human, mouse and rat homologues. To understand the potential role of nm23-C1 and -C2 in the development of mammary gland tumors (MGT), we analyzed the mRNA expression in 14 MGT samples by RT-PCR. The samples were divided into categories according to their histopathology (benign/malignant) and metastasis. No significant difference in the mRNA expression levels of either nm23-C1 or -C2 were observed between the benign and malignant groups or the metastatic and non-metastatic groups. These results suggest that nm23-C1 and -C2 are not related to the establishment of malignancy and metastatic lesions in canine MGT cases.
- 公益社団法人 日本獣医学会の論文
著者
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AKUZAWA Masao
Laboratory of Veterinary Internal Medicine
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Misumi Kazuhiro
Laboratory Of Veterinary Surgery Department Of Veterinary Medicine Faculty Of Agriculture Kagoshima
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Endo Yasuyuki
Laboratory Animal Research Center The Institute Of Medical Science The University Of Tokyo
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FUJIKI Makoto
Laboratory of Surgery, Joint Faculty of Veterinary Medicine, Kagoshima University, 1–21–24 Korimoto, Kagoshima 890–0065, Japan
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MIYOSHI Noriaki
Laboratory of Histopathology, Joint Faculty of Veterinary Medicine, Kagoshima University
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TAKAHASHI Masashi
Laboratory of Veterinary Internal Medicine, Faculty of Agriculture, Kagoshima University
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UNE Ryoma
Laboratory of Veterinary Internal Medicine, Faculty of Agriculture, Kagoshima University
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FUKUSHIMA Kenjiro
Laboratory of Veterinary Internal Medicine, Faculty of Agriculture, Kagoshima University
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OHISHI Akihiro
Laboratory of Veterinary Animal Hospital, Faculty of Agriculture, Kagoshima University
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FUJIKI Makoto
Laboratory of Surgery, Joint Faculty of Veterinary Medicine, Kagoshima University
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FUJIKI Makoto
Laboratory of Veterinary Surgery, Faculty of Agriculture, Kagoshima University
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AKUZAWA Masao
Laboratory of Veterinary Internal Medicine, Faculty of Agriculture, Kagoshima University
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