Pathological Features of Salivary Gland Cysts in a Shiba Dog with GM1 Gangliosidosis: A Possible Misdiagnosis as Malignancy

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概要

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• Salivary gland cysts are often concurrent with GM1 gangliosidosis in Shiba dogs. Although the etiology is unknown, these cysts may be misdiagnosed as malignant due to the accumulation of foamy cells. The present study investigated the cytological, histopathological, immunohistochemical and electron microscopic characteristics of salivary gland cysts in a Shiba dog affected with GM1 gangliosidosis. The salivary gland masses were surgically enucleated and examined clinicopathologically and pathologically in a 7-month-old Shiba dog with GM1 gangliosidosis. Many large cells with rich cytoplasm including vacuoles of various sizes, i.e., foamy cells, were observed in stamp smears from the cut-surface of the masses and histopathologically in major parts of the cyst wall. Some of these foamy cells presented features similar to a spider-web appearance. The foamy cells were confirmed to have originated from macrophages based on marked immunohistochemical expression of vimentin, HLA-DR, lysozyme and Iba1. An ultrastructural study demonstrated electron-dense vesicular structures in the vacuolated cells. Therefore, the masses were diagnosed pathologically as benign salivary gland cysts with accumulation of foamy cells. In conclusion, the histopathological features of the salivary gland cysts in this Shiba dog were similar to those of lipoma and/or liposarcoma. In such cases, immunohistochemical and ultrastructural examinations were useful in the differential diagnosis. Practitioners, clinical pathologists and pathologists should take GM1 gangliosidosis into consideration when they encounter salivary gland cysts in Shiba dogs.

著者

• Yamato Osamu

  Laboratory of Veterinary Internal Medicine, , Department of Veterinary Clinical Sciences, Graduate S

• Yabuki Akira

  Laboratory Of Veterinary Anatomy Department Of Veterinary Medicine Faculty Of Agriculture Kagoshima

• NAKAMOTO Yuya

  Kyoto Animal Medical Center

• OZAWA Tsuyoshi

  Kyoto Animal Medical Center

• Rahman Mohammad

  Laboratory Of Function And Morphology Department Of Animal Science Faculty Of Agriculture Utsunomiya

• KAWAGUCHI Hiroaki

  Laboratory of Pathology, Department of Veterinary Medicine, Kagoshima University

• MIYOSHI Noriaki

  Laboratory of Pathology, Department of Veterinary Medicine, Kagoshima University

• RAHMAN Mohammad

  Laboratory of Clinical Pathology, Department of Veterinary Medicine, Kagoshima University, Kagoshima 890-0065, Japan

• Rahman Mohammad

  Laboratory for Nanoelectronics and Spintronics, Research Institute of Electrical Communication, Tohoku University, Sendai 980-8577, Japan

• OZAWA Tsuyoshi

  Kyoto Animal Referral Medical Center, Kyoto 613-0036, Japan

• MIYOSHI Noriaki

  Laboratory of Pathology, Department of Veterinary Medicine, Kagoshima University, Kagoshima 890-0065, Japan

• YAMATO Osamu

  Laboratory of Clinical Pathology, Department of Veterinary Medicine, Kagoshima University, Kagoshima 890-0065, Japan

• YAMATO Osamu

  Laboratory of Clinical Pathology, Department of Veterinary Medicine, Kagoshima University

• NAKAMOTO Yuya

  Kyoto Animal Referral Medical Center, Kyoto 613-0036, Japan

• KAWAGUCHI Hiroaki

  Laboratory of Pathology, Department of Veterinary Medicine, Kagoshima University, Kagoshima 890-0065, Japan

• YABUKI Akira

  Laboratory of Clinical Pathology, Department of Veterinary Medicine, Kagoshima University

• Rahman Mohammad

  Laboratory for Nanoelectronics and Spintronics, Research Institute of Electrical Communication, Tohoku University, 2-1-1 Katahira, Aoba-ku, Sendai 980-8577, Japan

• MIYOSHI Noriaki

  Laboratory of Histopathology, Joint Faculty of Veterinary Medicine, Kagoshima University

• YABUKI Akira

  Laboratory of Clinical Pathology, Department of Veterinary Medicine, Joint Faculty of Veterinary Medicine, Kagoshima University

• YAMATO Osamu

  Laboratory of Clinical Pathology, Department of Veterinary Clinical Sciences, Faculty of Agriculture, Kagoshima University

• KAWAGUCHI Hiroaki

  Laboratory of Histopathology, Joint Faculty of Veterinary Medicine, Kagoshima University

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