SAMP1/Sku as a Murine Model for Tubulointerstitial Nephritis : a Study Using Unilateral Ureteral Obstruction
スポンサーリンク
概要
- 論文の詳細を見る
The SAMP1/Sku mouse is a substrain of the SAMP1 (senescence-accelerated-mouse prone 1) which exhibits renal mononuclear cell infiltration from a younger age. We hypothesized that this renal characteristic is related to the incidence of tubulointerstitial nephritis (TIN). The purpose of the present study was to evaluate the applicability of the SAMP1/Sku mouse as a murine model for TIN. TIN was experimentally induced by unilateral ureteral obstruction (UUO). The SAMP1/Sku and control ICR of both sexes received either a sham or UUO operation and were sacrificed 7 days after the operation. The kidneys of the mice were observed histopathologically, immunohistochemically and semiquantitatively. UUO kidneys showed mononuclear cell infiltration, tubular atrophy and interstitial fibrosis. In males, semiquantitative scores of mononuclear cell infiltration, tubular atrophy, and F4/80, α-smooth muscle actin (α-SMA) and transforming growth factor (TGF)-β1 reactions were significantly higher in SAMP1/Sku than in ICR. Likewise, in females, tubular atrophy and F4/80 reaction scores were significantly higher in SAMP1/Sku than in ICR. In conclusion, induction of TIN damage by UUO was more serious in SAMP1/Sku mice than in ICR. Therefore, we propose that SAMP1/Sku mice, especially male SAMP1/Sku, have congenital risk factors for the development of TIN.
- 社団法人 日本実験動物学会の論文
- 2005-01-01
著者
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MASUYAMA Taku
Toxicology Research Laboratories, Central Pharmaceutical Research Institute, Japan Tobacco Inc.
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松元 光春
鹿児島大学農学部家畜解剖学教室
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松元 光春
鹿大・農・獣医
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松本 光春
鹿児島大学 農学部 家畜内科学 教室
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YABUKI Akira
Laboratory of Veterinary Anatomy, Department of Veterinary Medicine
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MATSUMOTO Mitsuharu
Laboratory of Veterinary Anatomy, Department of Veterinary Medicine
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Yabuki A
中華人民共和国
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Yabuki Akira
Department Of Electrical Engineering And Information Science Yamagata University
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Suzuki S
Laboratory Of Veterinary Anatomy Faculty Of Agriculture Kagoshima University
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Suzuki Shusaku
Lab. Of Veterinary Anatomy Dep. Of Veterinary Medicine
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Kamimura R
Frontier Science Research Center Kagoshima University
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Kamimura Ryozo
Divison Of Laboratory Animal Science Research Center For Life Science Resources Kagoshima University
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Suzuki S
Department Of Veterinary Medicine Faculty Of Agriculture Kagoshima University
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Suzuki Syusaku
Laboratory Of Veterinary Anatomy
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MATSUMOTO Mitsuharu
Department of Veterinary Anatomy, Faculty of Agriculture, Kagoshima University
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Matsumoto M
Department Of Veterinary Anatomy Faculty Of Agriculture Kagoshima University
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Kamimura Ryouzou
Frontier Science Research Center Kagoshima University
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Yabuki Akira
Laboratory Of Veterinary Anatomy Department Of Veterinary Medicine Faculty Of Agriculture Kagoshima
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Suzuki Syusaku
Laboratory Of Veterinary Anatomy Department Of Veterinary Medicine Faculty Of Agriculture Kagoshima
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MAEDA Michie
Laboratory of Veterinary Anatomy, Faculty of Agriculture, Kagoshima University
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Maeda Michie
Laboratory Of Veterinary Anatomy Faculty Of Agriculture Kagoshima University
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Masuyama Taku
Toxicology Res. Laboratories Central Pharmaceutical Res. Inst. Japan Tobacco Inc.
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Masuyama Taku
Toxicology Research Laboratories Central Pharmaceutical Research Institute Japan Tobacco Inc.
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YABUKI Akira
Laboratory of Clinical Pathology, Department of Veterinary Medicine, Kagoshima University
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YABUKI Akira
Laboratory of Clinical Pathology, Department of Veterinary Medicine, Joint Faculty of Veterinary Medicine, Kagoshima University
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