Neuronal Nitric Oxide Synthase and Cyclooxygenase-2 in Diabetic Nephropathy of Type 2 Diabetic OLETF Rats
スポンサーリンク
概要
- 論文の詳細を見る
Neuronal nitric oxide synthase (nNOS) and cyclooxygenase-2 (COX-2) regulate the tubuloglomerular feedback (TGF) and renin-angiotensin system (RAS) in the kidney. In type 1 diabetic rats, renal overproduction of these enzymes and their relationship to the pathogenesis of diabetic nephropathy has been demonstrated. In the present study, we histologically and immunohistochemically investigated the kidneys of Otsuka Long-Evans Tokushima Fatty (OLETF) rats, as a model of type 2 diabetes, at 62 weeks of age (chronic phase of diabetes). The kidneys of OLETF rats showed typical diabetic nephropathy. Quantitative scores for glomerulosclerosis and interstitial fibrosis in OLETF rats were significantly higher than those of age-matched control Long-Evans Tokushima Otsuka (LETO) rats. nNOS- and COX-2-positive immunoreactions were observed in the distal tubules and collecting ducts. These reactions appeared to be more widely distributed in OLETF, and the number of nNOS-and COX-2-positive sites in the OLETF were significantly more than those in LETO rats. Expression of renin, angiotensin II, and inducible nitric oxide synthase (iNOS) were also examined immunohistochemically, and no differences between OLETF and LETO rats were observed in the distributions and the number of immunoreactive-sites. In conclusion, the overproduction of nNOS and COX-2 in the kidney of OLETF rats was confirmed, suggesting that the overproduction of nNOS and/or COX-2 does not affect the intrarenal RAS or iNOS production but does affect TGF.
- 社団法人 日本実験動物学会の論文
- 2006-01-01
著者
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松元 光春
鹿児島大学農学部家畜解剖学教室
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松元 光春
鹿大・農・獣医
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松本 光春
鹿児島大学 農学部 家畜内科学 教室
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YABUKI Akira
Laboratory of Veterinary Anatomy, Department of Veterinary Medicine
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MATSUMOTO Mitsuharu
Laboratory of Veterinary Anatomy, Department of Veterinary Medicine
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SUZUKI Shusaku
Laboratory of Veterinary Anatomy, Department of Veterinary Medicine
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TANIGUCHI Kazuyuki
Laboratory of Veterinary Anatomy, Iwate University
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Taniguchi K
Dep. Of Veterinary Anatomy School Of Veterinary Medicine And Animal Sciences Kitasato Univ.
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Taniguchi K
Steelmaking Research Section Iron And Steel Research Laboratories Kobe Steel Ltd.
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Tsuchiya K
Laboratory Of Paramedical Sciences Department Of Veterinary Medicine Faculty Of Agriculture Iwate Un
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Yabuki A
中華人民共和国
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Yabuki Akira
Department Of Electrical Engineering And Information Science Yamagata University
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Suzuki S
Laboratory Of Veterinary Anatomy Faculty Of Agriculture Kagoshima University
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Suzuki Shusaku
Lab. Of Veterinary Anatomy Dep. Of Veterinary Medicine
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Suzuki Shusaku
Laboratory Of Veterinary Anatomy
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鈴木 秀作
鹿児島大学 獣医解剖学
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Suzuki S
Department Of Veterinary Medicine Faculty Of Agriculture Kagoshima University
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TAHARA Tomonori
Department of Toxicology, Tokushima Research Institute, Otsuka Pharmaceutical Co. Ltd.
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MATSUMOTO Mitsuharu
Department of Veterinary Anatomy, Faculty of Agriculture, Kagoshima University
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Matsumoto M
Department Of Veterinary Anatomy Faculty Of Agriculture Kagoshima University
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Yabuki Akira
Laboratory Of Veterinary Anatomy Department Of Veterinary Medicine Faculty Of Agriculture Kagoshima
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Suzuki Syusaku
Laboratory Of Veterinary Anatomy Department Of Veterinary Medicine Faculty Of Agriculture Kagoshima
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Tahara Tomonori
Department Of Toxicology Tokushima Research Institute Otsuka Pharmaceutical Co. Ltd.
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Taniguchi Kazuyuki
Laboratory Of Veterinary Anatomy Iwate University
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YABUKI Akira
Laboratory of Clinical Pathology, Department of Veterinary Medicine, Kagoshima University
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YABUKI Akira
Laboratory of Clinical Pathology, Department of Veterinary Medicine, Joint Faculty of Veterinary Medicine, Kagoshima University
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Taniguchi Kazuyuki
Laboratory of Paramedical Sciences, Department of Veterinary Medicine, Iwate University
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