Neuronal Nitric Oxide Synthase and Cyclooxygenase-2 in Diabetic Nephropathy of Type 2 Diabetic OLETF Rats
スポンサーリンク
概要
- 論文の詳細を見る
Neuronal nitric oxide synthase (nNOS) and cyclooxygenase-2 (COX-2) regulate the tubuloglomerular feedback (TGF) and renin-angiotensin system (RAS) in the kidney. In type 1 diabetic rats, renal overproduction of these enzymes and their relationship to the pathogenesis of diabetic nephropathy has been demonstrated. In the present study, we histologically and immunohistochemically investigated the kidneys of Otsuka Long-Evans Tokushima Fatty (OLETF) rats, as a model of type 2 diabetes, at 62 weeks of age (chronic phase of diabetes). The kidneys of OLETF rats showed typical diabetic nephropathy. Quantitative scores for glomerulosclerosis and interstitial fibrosis in OLETF rats were significantly higher than those of age-matched control Long-Evans Tokushima Otsuka (LETO) rats. nNOS- and COX-2-positive immunoreactions were observed in the distal tubules and collecting ducts. These reactions appeared to be more widely distributed in OLETF, and the number of nNOS-and COX-2-positive sites in the OLETF were significantly more than those in LETO rats. Expression of renin, angiotensin II, and inducible nitric oxide synthase (iNOS) were also examined immunohistochemically, and no differences between OLETF and LETO rats were observed in the distributions and the number of immunoreactive-sites. In conclusion, the overproduction of nNOS and COX-2 in the kidney of OLETF rats was confirmed, suggesting that the overproduction of nNOS and/or COX-2 does not affect the intrarenal RAS or iNOS production but does affect TGF.
- 社団法人 日本実験動物学会の論文
- 2006-01-01
著者
-
松元 光春
鹿児島大学農学部家畜解剖学教室
-
松元 光春
鹿大・農・獣医
-
松本 光春
鹿児島大学 農学部 家畜内科学 教室
-
YABUKI Akira
Laboratory of Veterinary Anatomy, Department of Veterinary Medicine
-
MATSUMOTO Mitsuharu
Laboratory of Veterinary Anatomy, Department of Veterinary Medicine
-
SUZUKI Shusaku
Laboratory of Veterinary Anatomy, Department of Veterinary Medicine
-
TANIGUCHI Kazuyuki
Laboratory of Veterinary Anatomy, Iwate University
-
Taniguchi K
Dep. Of Veterinary Anatomy School Of Veterinary Medicine And Animal Sciences Kitasato Univ.
-
Taniguchi K
Steelmaking Research Section Iron And Steel Research Laboratories Kobe Steel Ltd.
-
Tsuchiya K
Laboratory Of Paramedical Sciences Department Of Veterinary Medicine Faculty Of Agriculture Iwate Un
-
Yabuki A
中華人民共和国
-
Yabuki Akira
Department Of Electrical Engineering And Information Science Yamagata University
-
Suzuki S
Laboratory Of Veterinary Anatomy Faculty Of Agriculture Kagoshima University
-
Suzuki Shusaku
Lab. Of Veterinary Anatomy Dep. Of Veterinary Medicine
-
Suzuki Shusaku
Laboratory Of Veterinary Anatomy
-
鈴木 秀作
鹿児島大学 獣医解剖学
-
Suzuki S
Department Of Veterinary Medicine Faculty Of Agriculture Kagoshima University
-
TAHARA Tomonori
Department of Toxicology, Tokushima Research Institute, Otsuka Pharmaceutical Co. Ltd.
-
MATSUMOTO Mitsuharu
Department of Veterinary Anatomy, Faculty of Agriculture, Kagoshima University
-
Matsumoto M
Department Of Veterinary Anatomy Faculty Of Agriculture Kagoshima University
-
Yabuki Akira
Laboratory Of Veterinary Anatomy Department Of Veterinary Medicine Faculty Of Agriculture Kagoshima
-
Suzuki Syusaku
Laboratory Of Veterinary Anatomy Department Of Veterinary Medicine Faculty Of Agriculture Kagoshima
-
Tahara Tomonori
Department Of Toxicology Tokushima Research Institute Otsuka Pharmaceutical Co. Ltd.
-
Taniguchi Kazuyuki
Laboratory Of Veterinary Anatomy Iwate University
-
YABUKI Akira
Laboratory of Clinical Pathology, Department of Veterinary Medicine, Kagoshima University
-
YABUKI Akira
Laboratory of Clinical Pathology, Department of Veterinary Medicine, Joint Faculty of Veterinary Medicine, Kagoshima University
-
Taniguchi Kazuyuki
Laboratory of Paramedical Sciences, Department of Veterinary Medicine, Iwate University
関連論文
- リュウキュウイノシシ(Sus scrofa riukiuanus)の下顎骨に関する多変量解析
- 2-II-28 ホモシステインおよび銅誘導性血管内皮細胞死のビタミンB_6による抑制作用(ビタミン学の原点・栄養学への21世紀的回帰, 日本ビタミン学会第59回大会)
- 2-II-18 ネコ乳がんFRM細胞の増殖に及ぼすビタミンB_6の効果(第56回大会一般研究発表)
- マウスの生殖周期にともなう乳頭の組織学的変化
- タヌキ Nyctereutes procyonoidesおよびアナグマMeles melesの長骨に関する組織計測学的研究
- タヌキNyctereutes procyonoidesとアナグマMeles melesの頭蓋の形態計測
- ラットの腎臓の組織構造における系統差(解剖学)
- クラウンミニブタの皮膚の形態
- Skin Morphology of the Clawn Miniature Pig
- 4倍体/2倍体キメラ胚におけるEGFP遺伝子導入4倍体細胞
- イノシシから分離された細胞病原性subgenomic RNAを含む欠損干渉粒子の関与する豚コレラウイルスの性状解析 (ウイルス学)
- Development of Large Sized Semi-continuous Casting Process
- Low Superheat Teeming with Electromagnetic Stirring
- ラット肝癌細胞dRLh84移植癌における新規なタンパク質PSPの発現抑制
- 天然記念物ツシマヤマネコの剖検例
- 1996年-97年に経験されたイリオモテヤマネコの保護および死亡例
- 未発症NODマウスの腎臓における形態計測学的研究(短報)(解剖学)
- 未発症NODマウスの腎臓における形態計測学的研究(短報)
- 腎臓の死後変化に対するマイクロウェーブ照射固定の効果(短報)(解剖学)
- DBA/2雌マウスの腎臓の形態における発情周期の影響
- DBA/2Cr雌マウスの腎尿細管における細胞質顆粒の検出および刷子縁の染色性, 各種固定法と染色法の比較(短報)(解剖学)
- 鹿児島の縄文, 弥生遺跡出土の動物遺体
- 縄文後期の草野貝塚出土の哺乳類遺体
- 古代遺跡出土の動物骨に関する研究 : VI.鹿児島県麦之浦貝塚出土骨の概要
- Neuronal Nitric Oxide Synthase and Cyclooxygenase-2 in Diabetic Nephropathy of Type 2 Diabetic OLETF Rats
- 古代遺跡出土の動物骨に関する研究 : IV.鹿児島県黒川洞穴出土骨の概要
- 古代遺跡出土の動物骨に関する研究 : V.鹿児島県高橋貝塚出土骨の概要
- 古代遺跡出土の動物骨に関する研究 : II.鹿児島県片野洞穴出土骨の概要
- Transient increase of TUNEL-positive cells on postnatal day 20 in the developing rat olfactory bulb
- 処女, 妊娠, 泌乳および離乳期のラット腹鼠径部第1乳腺に分布する動脈の内皮細胞に関する電顕的観察
- ラットの心臓から腹鼠径部乳腺への経路における動脈壁の形態計測学的研究
- 1-III-4ビタミンB_6の抗酸化作用と動脈硬化(第55回大会一般研究発表)
- Ultrastructure of the Olfactory Epithelium in a Flatfish, Barfin Flounder (Verasper moseri)
- 整備環境下で維持されたSPF C57BL/6Crマウスの腎臓の加齢による形態変化(解剖学)
- Change in VEGF Expression in Mouse Mammary Gland during Reproductive Cycle
- Immunohistochemical Localization of Nitric Oxide Synthase (NOS) in Mouse Mammary Gland during Reproductive Cycle
- 鹿児島県で発生した牛の血腫に関する臨床血液学的研究(IV) : 血小板の電子顕微鏡的検索
- 難治性血腫を発症した黒毛和種牛における血小板凝集不全と大顆粒性好酸球
- 口之島野生化牛の筋組織に関する組織計測学的研究
- 齧歯目における賢臓の短および長ループネフロンの比率の種差
- 齧歯目の腎臓の組織構造における種差(解剖学)
- DBA/2Crマウス腎臓の雌雄差-成長期における雌雄差の発現(解剖学)
- 絶食マウスの乳腺の脂肪細胞と毛細血管の微細構造
- 成熟マウスにおける卵巣除去ならびに卵巣ホルモン投与が乳腺の実質と血管の発達に及ぼす影響
- C57BL/6マウス腎臓の加齢変化の雌雄差に関する形態計測学的研究
- ビタミンA欠乏ハムスターへのビタミンA投与による精細管ステージ同期化
- マウス乳腺の毛細血管におけるフェリチンの透過性
- 卵巣除去未成熟マウスの乳腺の血管におよぼすエストロジェンおよびプロジェステロン投与の影響
- エストロジェンおよびプロジェステロンが卵巣除去マウスの乳腺と血管の発達に及ぼす影響
- 妊娠および泌乳期のマウス乳腺における毛細血管の微細構造
- 摘出ブタおよびウシ脳底動脈の血管緊張の内皮による修飾
- 摘出ウマ冠状動脈のヒスタミンによる収縮・弛緩へのH_1受容体の関与
- Renin, Cyclooxygenase-2 and Neuronal Nitric Oxide Synthase in the Kidneys of Transgenic Tsukuba Hypertensive Mouse
- Fine Structure of the Parotid and Mandibular Glands of the Cotton Rat (Sigmodon hispidus)
- Effectiveness of Angiotensin-Converting Enzyme Inhibitor or Angiotensin II Receptor Blocker on Atrial Natriuretic Peptide
- A-type Natriuretic Peptide Level in Hypertensive Transgenic Mice
- Sex and Strain Differences in the Brush Border and PAS-Positive Granules and Giant Bodies of the Mouse Renal S3 Segment Cells
- Effects of Administration of Pilocarpine on the Aciner Cells of Parotid and Mandibuler Glands of the Mice
- Fine Structure of the Bovine Mandibular Gland
- Arteriosclerosis in the Influx and Intravisceral Arteries of the Liver, Kidney and Lung of WHHL Rabbits
- Vitamin B_6 Suppresses Growth of the Feline Mammary Tumor Cell Line FRM
- Perchloric acid-soluble protein is accumulated in nuclei by ER-stressors
- Gene and Protein Expression of Cartilage Oligomeric Matrix Protein Associated with Oncogenesis in Canine Tumors
- 犬および猫の腎不全におけるシクロオキシゲナーゼ-２およびNO合成酵素-１の発現
- Piezoelectric Linear Motors for Driving Head Element of CD-ROM ( FERROELECTRIC MATERIALS AND THEIR APPLICATIONS)
- 雌DBA/2マウスの腎臓の形態における加齢変化
- チャイニ-ズハムスタ-の下顎腺の微細構造について〔英文〕
- ヤギ耳下腺の走査電子顕微鏡による観察
- ウシの耳下腺の微細構造について
- チャイニ-ズハムスタ-の耳下腺の微細構造について〔英文〕
- 犬耳下腺の走査電子顕微鏡による観察
- 鹿児島の縄文,弥生遺跡出土のイヌの骨
- 卵巣除去マウスの乳腺組織ならびにその血管の構造におよぼすホルモン投与の影響
- Promoting Effects of Chinese Pangolin and Wild Pink Medicines on the Mammary Gland Development in Immature Mice
- SAMP1/Sku as a Murine Model for Tubulointerstitial Nephritis : a Study Using Unilateral Ureteral Obstruction
- Giant Lysosomes in The Renal Proximal Tubules ; A Morphological Characteristic of DBA/2 and DBA/1 Mouse Kidneys
- Life span and Renal Morphological Characterization of the SAMP1//Ka Mouse
- マウスのネフロン構成細胞の雌雄差および系統差に関する形態計測学的研究
- The Hemodynamic Effects of Acute Myocardial Ischemia and Reperfusion in Clawn Miniature Pigs
- Salt Water Promotes Hypertension in Dahl-S Rats
- Atrial Natriuretic Peptide (ANP)-Granules of Auricular Cardiocytes in Dehydrated and Rehydrated Mice
- Fine Structure of the Parotid Gland in Tree Shrew (Tupaia glis)
- Pharmacological Detection of an Integrity of Endothelium in Pig, Cattle and Horse Basilar Arteries in Vitro
- Cartilage Oligomeric Matrix Protein in Canine Spinal Cord Appears in the Cerebrospinal Fluid Associated With Intervertebral Disc Herniation
- KK-A[y]マウスの糖尿病性腎症におけるシクロオキシゲーゼ-2とレニンに関する免疫組織化学的検索
- Rodent Renal Structure Differs among Species
- Tetraploid Cells of Enhanced Green Fluorescent Protein Transgenic Mice in Tetraploid/Diploid-Chimeric Embryos
- A Seminal Plasma Haemagglutinin Isolated From the Surface of the Miniature Swine Sperm Is Derived From Seminal Vesicle
- マウス乳腺の実質と毛細血管の構造に関する透過電顕的観察 : 処女, 妊娠, 泌乳および退行期の変化
- マウスの乳腺組織とその血管構築に関する走査電顕的観察 : 処女, 妊娠, 泌乳および退行期の変化
- ツシマジカ,マゲシカ,ヤクシカの頭蓋の計測形態学的研究
- Histological and Morphometrical Studies on the Rat Nipple during the Reproductive Cycle
- Isolation of a Miniature Swine Seminal Plasma Haemagglutinin From the Sperm Surface
- Immunohistochemical Analysis of Cartilage-Derived Retinoic Acid-Sensitive Protein (CD-RAP)/Melanoma Inhibitory Activity (MIA) in Murine, Canine, Bovine, and Equine Cerebrospinal Tissues
- Life Span and Renal Morphological Characterization of the SAMP1//Ka Mouse
- 馬の頸椎損傷の画像診断例
- 犬および猫の腎不全におけるシクロオキシゲナーゼ-2およびNO合成酵素-1の発現
- ツシマジカ,マゲシカ,ヤクシカの頭蓋の計測形態学的研究
- Mammals from Archaeological Sites of the Jomon Period in Kagoshima Prefecture.
- Species Specific Differences in the Ratio of Short to Long Loop Nephrons in the Kidneys of Laboratory Rodents