Reference Values of Hematological and Biochemical Parameters for the World Smallest Microminipigs
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概要
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In this study, we demonstrated growth curves and reference values for hematological and serum biochemical parameters of Microminipigs, the world smallest experimental minipigs. In both male and female animals, the body weights (BWs) at 3 and 6 months of age were <5 kg and <10 kg, respectively, and growth curve revealed almost plateau (approximately 20 kg BW) after 18 months of age. Major hematological and serum biochemical parameters showed no gender differences and the values were very similar to those in Göttingen and Yukatan minipigs. The values obtained in this study can serve as fundamental reference, and thereby facilitate the use of Microminipig in life science research.
著者
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Izumi Hiroyuki
Drug Safety Research Laboratories Shin Nippon Biomedical Laboratories Ltd.
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Tanimoto Akihide
Department Of Molecular And Cellular Pathology Kagoshima University Graduate School Of Medical And D
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Miura Naoki
Veterinary Teaching Hospital Faculty Of Agriculture Kagoshima University
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KAWAGUCHI Hiroaki
Laboratory of Pathology, Department of Veterinary Medicine, Kagoshima University
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MIYOSHI Noriaki
Laboratory of Pathology, Department of Veterinary Medicine, Kagoshima University
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Hirakawa Kimiaki
鹿児島大学 農学部実験動物学
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Miyoshi Noriaki
Dep. Of Veterinary Histopathology Joint Fac. Of Veterinary Medicine Kagoshima Univ.
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YAMADA Tomonobu
Department of Molecular and Cellular Pathology, Kagoshima University Graduate School of Medical and Dental Sciences, 8–35–1 Sakuragaoka, Kagoshima 890–8544, Japan
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TAKAHASHI Yoshihiro
Drug Safety Research Laboratories, Shin Nippon Biomedical Laboratories, Ltd., 2438 Miyanoura, Kagoshima 891–1394, Japan
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YOSHIKAWA Tsuyoshi
Department of Molecular and Cellular Pathology, Kagoshima University Graduate School of Medical and Dental Sciences, 8–35–1 Sakuragaoka, Kagoshima 890–8544, Japan
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KAWARASAKI Tatsuo
Laboratory of Animal Reproduction, Department of Animal Science, School of Agriculture, Tokai University, Minamiaso, Aso, Kumamoto 869–1404, Japan
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YAMADA Tomonobu
Department of Molecular and Cellular Pathology, Kagoshima University Graduate School of Medical and Dental Sciences, 8–35–1 Sakuragaoka, Kagoshima 890–8544, Japan
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MIYOSHI Noriaki
Laboratory of Veterinary Histopathology, Joint Faculty of Veterinary Medicine, Kagoshima University, 1–21–24 Korimoto, Kagoshima 890–0065, Japan
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YOSHIKAWA Tsuyoshi
Department of Molecular and Cellular Pathology, Kagoshima University Graduate School of Medical and Dental Sciences, 8–35–1 Sakuragaoka, Kagoshima 890–8544, Japan
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KAWARASAKI Tatsuo
Laboratory of Animal Reproduction, Department of Animal Science, School of Agriculture, Tokai University, Minamiaso, Aso, Kumamoto 869–1404, Japan
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TANIMOTO Akihide
Department of Molecular and Cellular Pathology, Kagoshima University Graduate School of Medical and Dental Sciences, 8–35–1 Sakuragaoka, Kagoshima 890–8544, Japan
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KAWAGUCHI Hiroaki
Laboratory of Veterinary Histopathology, Joint Faculty of Veterinary Medicine, Kagoshima University, 1–21–24 Korimoto, Kagoshima 890–0065, Japan
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MIURA Naoki
Veterinary Teaching Hospital, Joint Faculty of Veterinary Medicine, Kagoshima University, 1–21–24 Korimoto, Kagoshima 890–0065, Japan
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TAKAHASHI Yoshihiro
Drug Safety Research Laboratories, Shin Nippon Biomedical Laboratories, Ltd., 2438 Miyanoura, Kagoshima 891–1394, Japan
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MIYOSHI Noriaki
Laboratory of Histopathology, Joint Faculty of Veterinary Medicine, Kagoshima University
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KAWAGUCHI Hiroaki
Laboratory of Histopathology, Joint Faculty of Veterinary Medicine, Kagoshima University
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IZUMI Hiroyuki
Drug Safety Research Laboratories, Shin Nippon Biomedical Laboratories, Ltd., 2438 Miyanoura, Kagoshima 891–1394, Japan
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