Effects of Fetal Exposure to Diethylstilbestrol on Mammary Tumorigenesis in Rats
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概要
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The aim of this study was to investigate the effect of fetal exposure to diethylstilbestrol (DES) on the induction of mammary tumors induced by 7,12-dimethylbenz[a]anthracene (DMBA) in female rats. Pregnant rats were fed only normal diet, diet mixed with 0.1 ppm DES throughout pregnancy period or diet mixed with 0.1, 1 or 10 ppm DES from day 13 of pregnancy till the end of pregnancy. Delivered pups were given 10 mg DMBA by gastric intubation at 50 days after birth and observed till 336 days after birth. Some rats exposed to DES throughout pregnancy and those from day 13 till the end of pregnancy showed endocrine disrupting effects such as absence of CL and active lactation in mammary glands at necropsy, while no abnormal estrus cycle such as persistent estrus was seen during the observation period until 88 days after birth. Fetal exposure to 0.1 ppm DES throughout pregnancy period, 0.1 and 1 ppm DES from day 13 of pregnancy increased the incidence and number of mammary carcinomas (MCs) at the earlier period while exposure to 0.1 ppm DES throughout pregnancy period enhanced the incidence and number of benign proliferative lesions (PLs) at the later period. MCs appeared earlier than benign PLs. These results suggest that exposure to DES throughout pregnancy and from day 13 of pregnancy could induce endocrine disrupting conditions and enhance the induction of MCs and that exposure to DES throughout pregnancy enhance PLs.
- 社団法人 日本獣医学会の論文
著者
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Miyoshi Noriaki
Department of Veterinary Pathology, Faculty of Agriculture, Kagoshima University, Japan
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Miura Naoki
Department Of Veterinary Medicine Faculty Of Agriculture Kagoshima University
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Yoshida Hiroki
Department Of Biomolecular Sciences Faculty Of Medicine Saga University
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YASUDA Nobuhiro
Department of Chemistry and Materials Science, Tokyo Institute of Technology
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Kawaguchi Hiroaki
Department Of Inf. Science Shonan Institute Of Technology
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Souda Masakazu
Department Of Tumor Pathology Field Of Oncology Kagoshima University Graduate School Of Medical And
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MIYAMOTO Yoko
Department of Information and Communication Engineering, The University of Electro-Communications
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Umekita Yoshihisa
Department Of Pathology Faculty Of Medicine Kagoshima University
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Miyoshi Noriaki
Dep. Of Veterinary Pathology Fac. Of Agriculture Kagoshima Univ. Jpn
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Miyamoto Yoko
Department Of Information And Communication Engineering The University Of Electro-communications
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Kawaguchi Hiroaki
Department Of Veterinary Experimental Animal Science Faculty Of Agriculture Kagoshima University
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Miyoshi Noriaki
Department Of Veterinary Pathology Faculty Of Agriculture Kagoshima University
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Hirakawa Kimiaki
鹿児島大学 農学部実験動物学
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YOSHIDA Hiroki
Department of Biochemistry, Microbiology, and Clinical Pharmacy, Graduate School of Clinical Pharmacy, Kyushu University of Health and Welfare
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