Effects of Oral Administration of Probiotics from Mongolian Dairy Products on the Th1 Immune Response in Mice
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概要
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We investigated 10 lactic acid bacteria strains with probiotic potential prepared from Mongolian dairy products for their ability to induce T helper type-1 (Th1) cytokine production in mouse immune cells in vitro and in vivo. Among these strains, the Lactobacillus plantarum 06CC2 strain was effective in elevating the level of interleukin (IL)-12p40 in co-culture with J774.1 cells and the levels of IL-12 and interferon (IFN)-γ in co-culture with mouse spleen cells in vitro. Oral administration of this strain augmented the gene expression of IFN-γ and IL-12p40 and enlarged the population of CD4+, CD25+, and CD49b+ cells in the spleens of normal mice. It also significantly elevated the gene expression of IL-12 receptor β2 as well as IL-12p40 and IFN-γ in Peyer's patches. Thus oral administration of strain 06CC2 was effective in inducing Th1 cytokine production activating the Th1 immune response associated with intestinal immunity in normal mice.
著者
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Yoshida Hiroki
Department Of Biomolecular Sciences Faculty Of Medicine Saga University
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Muguruma Michio
Department of Biochemistry and Applied Biosciences, Faculty of Agriculture, University of Miyazaki
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Kurokawa Masahiko
Department Of Biochemistry School Of Pharmaceutical Sciences Kyushu University Of Health And Welfare
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Muguruma Michio
Department Of Animal Science Faculty Of Agriculture Kyushu University
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Watanabe Wataru
Department Of Applied Physics Graduate School Of Engineering Osaka University
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Kawahara Satoshi
Department Of Biochemistry And Applied Biosciences Faculty Of Agriculture
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Takeshita Masahiko
Research Division Minami Nippon Dairy
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Kikuchi Yukiharu
Research And Development Division Minami Nippon Dairy Co-op Co. Ltd.
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HIDAKA Muneaki
Department of Biochemistry, Microbiology, and Clinical Pharmacy, Graduate School of Clinical Pharmacy, Kyushu University of Health and Welfare
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WATANABE Wataru
Department of Biochemistry, Microbiology, and Clinical Pharmacy, Graduate School of Clinical Pharmacy, Kyushu University of Health and Welfare
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TAKEDA Shiro
Research Division, Minami Nihon Rakuno Kyodo Co., Ltd.
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BUMBEIN Dashnyam
Mongolian Biotechnology Association
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KUROKAWA Masahiko
Department of Biochemistry, Microbiology, and Clinical Pharmacy, Graduate School of Clinical Pharmacy, Kyushu University of Health and Welfare
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YOSHIDA Hiroki
Department of Biochemistry, Microbiology, and Clinical Pharmacy, Graduate School of Clinical Pharmacy, Kyushu University of Health and Welfare
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