Effect of Platelet-Activating Factor Receptor Antagonist, Etizolam, on Resolution of Chronic Subdural Hematoma : A Prospective Study to Investigate Use as Conservative Therapy
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概要
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rights: 本文データは日本脳神経外科学会の許諾に基づきCiNiiから複製したものであInflammatory reaction is very important for formation of the neomembrane of chronic subdural hematoma (CSDH). The present study evaluated medical treatment with the platelet-activating factor receptor antagonist, etizolam, for the resolution of CSDH, and the factors indicating surgery or conservative therapy. Alternate patients were assigned to the etizolam group or control group without medical treatment. Patients in the etizolam group received 3.0mg etizolam per day for 14 days. A total of 53 patients were followed up for at least 6 months. Univariate analysis of differences in demographic characteristics, clinical findings, and initial computed tomography (CT) findings, and multiple logistic regression analysis of the relationship between etizolam treatment and requirement for surgery using age, sex, low density of hematoma on CT, and paresis as confounders were performed. Etizolam treatment (adjusted odds ratio [OR] 0.156, 95% confidence interval [CI] 0.024-0.999, p=0.049) was negatively correlated with requirement for surgery. Low density of hematoma (adjusted OR 0.125, 95% CI 0.019-0.846, p=0.033) was found to be an independent negative predictor, and paresis as an initial symptom (adjusted OR 6.35, 95% CI 1.04-38.7, p=0.045) was an independent positive predictor of requirement for surgery. Etizolam administration can promote the resolution of CSDH, especially at the stage of hygroma appearing as low density on CT. Surgery is recommended if the patient presents with paresis.
- 日本脳神経外科学会の論文
- 2005-12-15
著者
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HORI Emiko
Department of Neurosurgery, Aomori Prefectural Central Hospital
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KURIMOTO Masanori
Department of Neurosurgery, Faculty of Medicine, University of Toyama
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NAGAI Shoichi
Department of Neurosurgery, Faculty of Medicine, University of Toyama
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ENDO Shunro
Department of Neurosurgery, Faculty of Medicine, University of Toyama
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HIRASHIMA Yutaka
Department of Neurosurgery, University of Toyama
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Origasa Hideki
Department Of Biostatistics University Of Toyama
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Origasa Hideki
Division Of Biostatistics Faculty Of Medicine University Of Toyama
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Hirashima Yutaka
Physiological Chemistry Faculty Of Pharmaceutical Sciences Teikyo University
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Hori Emiko
Department Of Neurosurgery Faculty Of Medicine University Of Toyama
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Hori Emiko
Department Of Neurosurgery Aomori Prefectural Central Hospital
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Nagai Shoichi
Department Of Neurosurgery Faculty Of Medicine University Of Toyama
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Origasa Hideki
Department Of Biostatistics Faculty Of Medicine Toyama Medical And Pharmaceutical University
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Kurokawa M
School Of Medicine Toyama Medical And Pharmaceutical University
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Kurokawa Masahiko
Department Of Biochemistry School Of Pharmaceutical Sciences Kyushu University Of Health And Welfare
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Kurokawa Masahiko
Department Of Virology Facutly Of Medicine Toyama Medical And Pharmaceutical University
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Hirashima Yutaka
Departments Of Neurosurgery Toyama Medical And Pharmaceutical University
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Kurimoto Masanori
Department Of Neurosurgery Faculty Of Medicine University Of Toyama
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Endo Shunro
Department Of Neurosurgery Faculty Of Medicine University Of Toyama
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Kurimoto Masanori
Department Of Neurosurgery Toyama Medical And Pharmaceutical University
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Kurimoto Masanori
Department Of Bioproduction Faculty Of Agriculture Yamagata University
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Hirashima Yutaka
Department Of Neurosurgery Toyama Medical And Pharmaceutical University
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Hirashima Yutaka
Department of Materials Science, Toyohashi University of Technology
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