Hypothermia during Ischemia Protects against Neuronal Death but Not Acute Brain Edema following Transient Forebrain Ischemia in Mice
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概要
- 論文の詳細を見る
C57BL/6J mice are widely used as a background strain for genetic alterations and have been valuable for investigating the molecular mechanism of selective neuronal death following transient forebrain ischemia, which was induced by occlusion of bilateral common carotid arteries (BCCA). Hypothermia (HT) during ischemia has been shown to protect against neuronal death in several experimental models of cerebral ischemia including that induced by BCCA occlusion in C57BL/6J mice. In this study, we demonstrated that brain edema, one of the most important disorders following cerebral ischemia, occurred in the forebrain before neuronal death in the hippocampus and was not prevented by HT during cerebral ischemia induced by BCCA occlusion in C57BL/6J mice. Our results indicate that neuronal death and acute brain edema were induced by different mechanisms in the BCCA occlusion and reperfusion C57BL/6J mouse model, suggesting that our model with and without HT during cerebral ischemia may be a useful tool for the investigation of the specific mechanism of brain edema and neuronal death, respectively.
- 公益社団法人 日本薬学会の論文
著者
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HIRASHIMA Yutaka
Department of Neurosurgery, University of Toyama
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Doshi Masaru
Department Of Hematology Research Institute International Medical Center Of Japan
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Sasahara Masakiyo
Department Of Pathology 2 Toyama Medical And Pharmaceutical University Faculty Of Medicine
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Ishii Yoko
Department Of Pathology Graduate School Of Medicine And Pharmaceutical Sciences University Of Toyama
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Kuwatori Yudai
Department of Physiological Chemistry, Faculty of Pharmaceutical Sciences, Teikyo University
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Hirashima Yutaka
Department Of Neurosurgery Toyama Medical And Pharmaceutical University
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Ishii Yoko
Department Of Food And Nutrition Japan Women's University
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Sasahara Masakiyo
Department of Pathology, Graduate School of Medicine and Pharmaceutical Sciences for Research, University of Toyama
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Ishii Yoko
Department of Pathology, Graduate School of Medicine and Pharmaceutical Sciences for Research, University of Toyama
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Ishii Yoko
Department of Electronical Engineering and Bioscience, School of Science and Engineering, Waseda University, Shinjuku, Tokyo 169-8555, Japan
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Sasahara Masakiyo
Department of Neurosurgery, Kyoto University Faculty of Medicine
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Hirashima Yutaka
Department of Materials Science, Toyohashi University of Technology
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