Effect of a Platelet-Activating Factor Receptor Antagonist, E5880, on Cerebral Vasospasm after Aneurysmal Subarachnoid Hemorrhage : Open Clinical Trial to Investigate Efficacy and Safety
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概要
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rights: 本文データは日本脳神経外科学会の許諾に基づきCiNiiから複製したものであるThe efficacy and safety of a new platelet-activating factor receptor antagonist, E5880, were investigated for preventing cerebral vasospasm after subarachnoid hemorrhage (SAH) in 71 patients with SAH who underwent surgery for ruptured aneurysms within 3 days. Intravenous E5880 administration (300 μg or 1200 μg twice daily) was begun within 4 days and continued for 14 days. The incidence of symptomatic vasospasm, low-density area on computed tomography, and angiographic vasospasm was lower than in placebo groups in previous studies. Clinical outcome was favorable compared with previous studies. No clinically important adverse events were observed. These results suggest that E5880 is safe and effective in the treatment of patients with cerebral vasospasm due to SAH.
- 日本脳神経外科学会の論文
- 2001-04-15
著者
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ENDO Shunro
Department of Neurosurgery, Faculty of Medicine, University of Toyama
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HIRASHIMA Yutaka
Department of Neurosurgery, University of Toyama
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KOBAYASHI Naoki
Department of Physics, Chuo University
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Hirashima Yutaka
Physiological Chemistry Faculty Of Pharmaceutical Sciences Teikyo University
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TAKAKU Akira
Department of Neurosurgery, Toyama Medical and Pharmaceutical University, Toyama
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Asahi Takashi
Department Of Neurosurgery Faculty Of Medicine University Of Toyama
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赤井 卓也
国立水戸病院脳神経外科
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NUKUI Hideaki
Department of Neurosurgery, University of Yamanashi Faculty of Medicine
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Hirashima Yutaka
Departments Of Neurosurgery Toyama Medical And Pharmaceutical University
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Takaku Akira
Department Of Neurosurgery Faculty Of Medicine University Of Toyama
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Nukui Hideaki
Department Of Neurosurgery And Radiology Yamanashi Medical University And Department Of Radiology To
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Nukui Hideaki
Department Of Neurosurgery Yamanashi Medical University
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Asahi Takashi
Faculty Of Medicine Department Of Physiology Toyama Medical And Pharmaceutical University
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Asahi Takashi
Departments Of Neurosurgery Toyama Medical And Pharmaceutical University
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Endo Shunro
Department Of Neurosurgery Faculty Of Medicine University Of Toyama
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Akai Takuya
Department Of Neurosurgery Faculty Of Medicine University Of Toyama
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Kobayashi Naoki
Department Of Orthopaedic Surgery Dokkyo University School Of Medicine
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Kobayashi Naoki
Department Of Chemistry Faculty Of Science And Technology Keio University
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Kobayashi Naoki
Department Of Radiology Institute Of Neurology Ebina General Hospital East
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Kobayashi Naoki
Department Of Applied Physics And Chemistry The University Of Electro-communications
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Hirashima Yutaka
Department Of Neurosurgery Toyama Medical And Pharmaceutical University
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Kobayshi Naoki
Department of Radiology, Institute of Neurology, Ebina General Hospital East
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赤井 卓也
Department of Neurosurgery, Faculty of Medicine, University of Toyama
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Hirashima Yutaka
Department of Materials Science, Toyohashi University of Technology
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