Prognostic Factors in Elderly Patients with Supratentorial Malignant Gliomas
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概要
- 論文の詳細を見る
rights: 本文データは,社団法人 日本脳神経外科学会の許諾に基づき,CiNiiから複製したものであるThe prognostic factors were retrospectively analyzed in 30 patients aged 70 years or over with supratentorial malignant gliomas treated by surgery in our hospital. The histological diagnosis was confirmed as grade 3 in 13 patients and grade 4 in 17. Seventeen patients received adjuvant radiation therapy. Only 10 patients underwent chemotherapy. Survival time was analyzed with the Kaplan-Meier method. Prognostic factors were obtained from the Cox proportional hazards model. Univariate analysis showed preoperative Karnofsky performance status (KPS) score of 70 or greater and radiation therapy were significantly associated with longer survival. However, multivariate analysis revealed that preoperative KPS score of 70 or greater was the only independent prognostic factor and radiation therapy lost its significance due to selection bias. Neurological deterioration and medical complications occurred in six and seven patients, respectively. Performance status rather than histological grade is the key prognostic factor in elderly patients with supratentorial malignant gliomas. Patients with good preoperative KPS score should be aggressively treated with extensive resection and radiotherapy.
- 社団法人 日本脳神経外科学会の論文
- 2007-12-15
著者
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ORIGASA Hideki
Division of Biostatistics and Clinical Epidemiology, University of Toyama School of Medicine
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KURIMOTO Masanori
Department of Neurosurgery, Faculty of Medicine, University of Toyama
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NAGAI Shoichi
Department of Neurosurgery, Faculty of Medicine, University of Toyama
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HAYASHI Nakamasa
Department of Neurosurgery, Faculty of Medicine, University of Toyama
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ENDO Shunro
Department of Neurosurgery, Faculty of Medicine, University of Toyama
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Origasa Hideki
Division Of Biostatistics Faculty Of Medicine University Of Toyama
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TSUBOI Yoshifumi
Department of Neurosurgery, Faculty of Medicine, University of Toyama
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KAMIYAMA Hironaga
Departments of Neurosurgery, Aomori Prefectural Central Hospital
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Nagai Shoichi
Department Of Neurosurgery Faculty Of Medicine University Of Toyama
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Kurokawa M
School Of Medicine Toyama Medical And Pharmaceutical University
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Kurokawa Masahiko
Department Of Biochemistry School Of Pharmaceutical Sciences Kyushu University Of Health And Welfare
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Kurokawa Masahiko
Department Of Virology Facutly Of Medicine Toyama Medical And Pharmaceutical University
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Endo S
Department Of Neurosurgery Faculty Of Medicine University Of Toyama
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Hayashi Nakamasa
Department Of Neurosurgery Faculty Of Medicine University Of Toyama
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Hayashi Nakamasa
Department Of Neurosurgery Aomori Prefectural Central Hospital
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KUROSAKI Kunikazu
Department of Neurosurgery, University of Toyama
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Tsuboi Yoshifumi
Department Of Neurosurgery Faculty Of Medicine University Of Toyama
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Kurimoto Masanori
Department Of Neurosurgery Faculty Of Medicine University Of Toyama
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Kurosaki Kunikazu
Department Of Neurosurgery Faculty Of Medicine University Of Toyama
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Kamiyama Hironaga
Department Of Neurosurgery Aomori Prefectural Central Hospital
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Kamiyama Hironaga
Osaka University Graduate School Of Medicine
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Endo Shunro
Department Of Neurosurgery Faculty Of Medicine University Of Toyama
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Endo Shunro
Faculty Of Medicine Department Of Neurosurgery Toyama Medical And Pharmaceutical University
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Kurimoto Masanori
Department Of Neurosurgery Toyama Medical And Pharmaceutical University
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Endo Shunro
Departments Of Neurosurgery Toyama Medical And Pharmaceutical University
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Origasa Hideki
Division Of Biostatistics And Clinical Epidemiology University Of Toyama Graduate School Of Medicine
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Kurimoto Masanori
Department Of Bioproduction Faculty Of Agriculture Yamagata University
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