Anti-Herpes Simplex Virus Activity of Alkaloids Isolated from Stephania cepharantha
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概要
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By screening water and MeOH extracts of 30 Chinese medicinal plants for their anti-herpes simplex virus (HSV)-1 activity, a MeOH extract of the root tubers of Stephania cepharantha HAYATA showed the most potent activity on the plaque reduction assay with an IC_<50> value of 18.0 μg/ml. Of 49 alkaloids isolated from the MeOH extract, 17 alkaloids were found to be active against HSV-1,including 13 bisbenzylisoquinoline, 1 protoberberine, 2 morphinane and 1 proaporphine alkaloids, while benzylisoquinoline and hasubanane alkaloids were inactive. Although N-methylcrotsparine was active against HSV-1,as well as HSV-1 thymidine kinase deficient (acyclovir resistant type, HSV-1 TK^-)and HSV-2 (IC_<50> values of 8.3,7.7 and 6.7 μg/ml, respectively), it was cytotoxic. FK-3000 was found to be the most active against HSV-1,HSV-1 TK^- and HSV-2 (IC_<50> values of 7.8,9.9 and 8.7 μg/ml) with in vitro therapeutic indices of 90,71 and 81,respectively. FK-3000 was found to be a promising candidate as an anti-HSV agent against HSV-1,acyclovir (ACV) resistant-type HSV-1 and HSV-2.
- 公益社団法人日本薬学会の論文
- 1999-03-15
著者
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MA Chao-Mei
Institute of Natural Medicine, University of Toyama
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Ma Chao-mei
富山大学和漢医薬学総合研究所
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Hattori Masao
Research Institute For Wakan-yaku (traditional Sino-japanese Medicines) Toyama Medical And Pharmaceu
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NAKAMURA Norio
Research Institute for Wakan-Yaku, Toyama Medical and Pharmaceutical University
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KUROKAWA Masahiko
School of Medicine, Toyama Medical and Pharmaceutical University
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SHIRAKI Kimiyasu
School of Medicine, Toyama Medical and Pharmaceutical University
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Kurokawa M
School Of Medicine Toyama Medical And Pharmaceutical University
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Kurokawa Masahiko
Department Of Biochemistry School Of Pharmaceutical Sciences Kyushu University Of Health And Welfare
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Kurokawa Masahiko
Department Of Virology Facutly Of Medicine Toyama Medical And Pharmaceutical University
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Nakamura N
Institute Of Natural Medicine Toyama Medical And Pharmaceutical University
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Ono Minoru
Research Laboratories Kaken Shoyaku Co. Ltd.
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KASHIWABA Noriaki
Research Laboratories, Kaken Shoyaku Co., Ltd.,
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Shiraki Kimiyasu
Department Of Virology Graduate School Of Medicine And Pharmaceutical Sciences University Of Toyama
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Shiraki Kimiyasu
School Of Medicine Toyama Medical And Pharmaceutical University
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Kurimoto Masanori
Department Of Neurosurgery Toyama Medical And Pharmaceutical University
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Shiraki K
Department Of Virology Graduate School Of Medicine And Pharmaceutical Sciences University Of Toyama
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MA Chao-mei
Research Institute for Wakan-Yaku (Traditional Sino-Japanese Medicines) Toyama Medical and Pharmaceu
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Kashiwaba Noriaki
Research Laboratories Kaken Shoyaku Co. Ltd.
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Nakamura Norio
Research Institute For Wakan-yaku (oriental Medicines) Toyama Medical And Pharmaceutical University
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HATTORI MASAO
Research Institute for Wakan-Yaku (Oriental Medicines)
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