Transformation of Ergosterol Peroxide to Cytotoxic Substances by Rat Intestinal Bacteria(Biopharmacy)
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概要
- 論文の詳細を見る
Ergosterol peroxide (EPO, 1) is a major antitumor sterol produced by edible or medicinal mushrooms. Following oral administration of 1 to rats or anaerobic in vitro incubation of 1 with rat fecal bacteria, three metabolites were detected and their structures were identified to be 5a,6a-epoxyergosta-8(14),22-diene-3β,7α-diol (M1,2), 5α,6α-epoxyergosta-8,22-diene-3β,7α-diol (M2,3), and 5α,6α-epoxy-3β-hydroxyergosta-22-ene-7-one (M3,4) by spectroscopic analysis. Of these, M2 and M3 showed more potent inhibitory activity than the original compound 1 against proliferation of CACO-2, WiDr, DLD-1 and Colo320 human colorectal adenocarcinoma cells. These findings suggest that bacterial metabolites of EPO play a significant role in its cytotoxic activity against human colorectal cancer cells.
- 公益社団法人日本薬学会の論文
- 2008-05-01
著者
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服部 征雄
富山大学和漢医薬学総合研究所
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HATTORI Masao
Division of Metabolic Engineering, Institute of Natural Medicine, University of Toyama
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MA Chao-Mei
Institute of Natural Medicine, University of Toyama
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Ma Chao-mei
富山大学和漢医薬学総合研究所
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Hattori M
Inst. Of Natural Medicine Univ. Of Toyama
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Hattori M
Research Institute For Wakan-yaku Toyama Medical And Pharmaceutical University
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Hattori Masao
Department Of Metabolic Engineering Institute Of Natural Medicine Toyama Medical And Pharmaceutical
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Ma Chao-mei
Division Of Metabolic Engineering Institute Of Natural Medicine University Of Toyama
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Lee Joo-sang
Division Of Metabolic Engineering Institute Of Natural Medicine University Of Toyama
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PARK Dong-Ki
Department of Applied Biology and Chemistry, Konkuk University
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YOSHIMI Yasuharu
Department of Applied Chemistry and Biotechnology, Faculty of Engineering, University of Fukui
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HATANAKA Minoru
Department of Applied Chemistry and Biotechnology, Faculty of Engineering, University of Fukui
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Hattori M
Institute Of Natural Medicine University Of Toyama
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Hattori Masao
Division Of Metabolic Engineering Institute Of Natural Medicine University Of Toyama
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Park Dong-ki
Department Of Applied Biology And Chemistry Konkuk University
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Hatanaka Minoru
Department Of Applied Chemistry And Biotechnology Faculty Of Engineering Fukui University
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Hatanaka Minoru
Department Of Applied Chemistry And Biotechnology Faculty Of Engineering University Of Fukui
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Hattori Masao
Institute Of Natural Medicine Faculty Of Pharmaceutical Sciences
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Yoshimi Yasuharu
Department Of Applied Chemistry And Biotechnology Faculty Of Engineering University Of Fukui
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PARK Dong-Ki
Department fo Biochemistry, Kon-Kuk University, Choong Joo 380, Korea
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