Human Intestinal Bacteria Capable of Transforming Secoisolariciresinol Diglucoside to Mammalian Lignans, Enterodiol and Enterolactone

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概要

• 論文の詳細を見る

• Seven metabolites were isolated after anaerobic incubation of secoisolariciresinol diglucoside (1) with a human fecal suspension. They were identified as (-)-secoisolariciresinol (2), 3-demethyl-(-)-secoisolariciresinol (3), 2-(3-hydroxybenzyl)-3-(4-hydroxy-3-methoxybenzyl)butane-1,4-diol (4), didemethylsecoisolariciresinol (5), 2-(3-hydroxybenzyl)-3-(3,4-dihydroxybenzyl)butane-1,4-diol (6), enterodiol (7) and enterolactone (8).Furthermore, two bacterial strains, Peptostreptococcus sp. SDG-1 and Eubacterium sp. SDG-2,responsible for the transformation of 1 to a mammalian lignan 7,where isolated from a human fecal suspension. The former transformed 2 to 3 and 5,as well as 4 to 6,and the latter transformed 5 to 6 and 7.

• 公益社団法人日本薬学会の論文
• 2000-11-01

著者

• MESELHY Meselhy

  Institute of Natural Medicine, Faculty of Pharmaceutical Sciences and Pharmaceutical University

• Qin Guo-Wei

  Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences

• Wang Li-quan

  Institute Of Natural Medicine Toyama Medical And Pharmaceutical University:shanghai Institute Of Mat

• Wang Li-quan

  富山医科薬科大学和漢薬研究所

• Li Yong

  Department Of Chemistry Pukyong National University

• HATTORI Masao

  Institute of Natural Medicine, University of Toyama

• Li Y

  Institute Of Natural Medicine Toyama Medical And Pharmaceutical University

• Hattori M

  Research Institute For Wakan-yaku Toyama Medical And Pharmaceutical University

• Qin Guo-wei

  Shanghai Institute Of Materia Medica Chinese Academy Of Science

• LI Yan

  Institute of Natural Medicine, Toyama Medical and Pharmaceutical University

• Meselhy M

  Toyama Medical And Pharmaceutical Univ. Toyama Jpn

• Meselhy Meselhy

  Faculty Of Pharmacy Cairo University

• Meselhy Meselhy

  (present Address)faculty Of Pharmacy Cairo University

• Li Yan

  Institute Of Applied Physics Crest Japan Science And Technology Corporation (jst) University Of Tsuk

• Li Yan

  Key Laboratory Of Materials Physics Institute Of Solid State Physics Chinese Academy Of Sciences

• Li Y

  Graduate School Of Engineering Tottori University

• Li Yan

  Institute Of Medicinal Plant Development Chinese Academy Of Medical Sciences And Peking Union Medica

• Meselhy Meselhy

  Institute Of Natural Medicine Faculty Of Pharmaceutical Sciences And Pharmaceutical University

• Hattori Masao

  Institute Of Natural Medicine Faculty Of Pharmaceutical Sciences

• Qin Guo-wei

  Shanghai Inst. Of Materia Medica Shanghai Institutes For Biological Sciences

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