Granuloma Maturation in the Rat is Advanced by the Oral Administration of Eucommia ulmoides OLIVER Leaf

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概要

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• We have reported that collagen metabolism was improved by the administration of Eucommia ulmoides OLIVER leaf. In this paper, we examine the granuloma maturation and deposition of collagen in the granuloma of rats due to the oral administration of this leaf. After 3 weeks of the oral administration, granuloma formation was induced by the formalin soaked filter paper-pellet method. A week later, the developing granuloma was dissected. Granuloma formation was significantly increased due to ingestion of the dried leaf at a dose of 1.8 g/kg of body weight/d. The collagen content in the granuloma was also significantly increased. In the case of the collagen profile, the pepsin-solubilized collagen content and its relative percentage to the total collagen were significantly higher than in the control. Histochemical examination showed that the granuloma tissues were well developed, and displayed many newly synthesized capillary vessels and a greater quantity of fibroblasts and monocytes in the 1.8 g leaf group. High density lipoprotein (HDL)-cholesterol and triglyceride content in the blood plasma were significantly higher than in the control. These results show that granuloma maturation was accelerated and the energy was supplied from fatty acid metabolism. The administration of Eucommia ulmoides OLIVER leaf may be effective at speeding up the wound healing process.

• 公益社団法人日本薬学会の論文
• 2000-01-01

著者

• Sato T

  Department Of Pathological Biochemistry Kyoto Pharmaceutical University

• Sato Takashi

  Dep. Of Biochemistry And Molecular Biology Tokyo Univ. Of Pharmacy And Life Sciences School Of Pharm

• Motani Kou

  日本大学 薬学部臨床医学ユニット

• Li Yong

  Department Of Chemistry Pukyong National University

• Li Y

  Nihon Univ. Funabashi Jpn

• Metori Koichi

  Chemical Analytical Center College Of Pharmacy Nihon University

• Metori Koichi

  Coll. Of Pharmacy Nihon Univ.

• Metori Koichi

  Department Of Biochemistry College Of Pharmacy Nihon University

• Takahashi S

  秋田県農林水産技術センター総合食品研究所

• LI Yanmei

  Biochemistry Laboratory, College of Pharmacy, Nihon University

• KOIKE Katsuya

  Biochemistry Laboratory, College of Pharmacy, Nihon University

• KITA Fumio

  Research and Development Division, SS Pharmaceutical Co., Ltd.,

• CHE Qing-ming

  Department of Traditional Chinese Medicine, School of Pharmaceutical Science, Beijing Medical Univer

• SATO Tuneo

  College of Bioresource Sciences, Nihon University

• SHIRAI Wataru

  College of Bioresource Sciences, Nihon University

• TAKAHASHI Shushichi

  College of Industrial Technology, Nihon University

• Li Yanmei

  Biochemistry Laboratory College Of Pharmacy Nihon University

• Kita Fumio

  Research And Development Division Ss Pharmaceutical Co. Ltd.

• Koike K

  Biochemistry Laboratory College Of Pharmacy Nihon University

• Koike Katsuya

  Biochemistry Laboratory College Of Pharmacy Nihon University

• Shirai Wataru

  College Of Bioresource Sciences Nihon University

• Che Qing-ming

  Department Of Traditional Chinese Medicine School Of Pharmaceutical Science Beijing Medical Universi

• Metori K

  College Of Pharmacy Nihon University

• Lu Y.M.

  Changchun Institute of Physics Academia Sinica

• Li Y

  Cancer Institute Peking Union Medical College And Chinese Academy Of Medical Sciences

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