Measurement of Inclusion Complex Formation between Cyclophane and Biological Relevant Amino Acids Using Electrospray Ionization, Cold-Spray Ionization and Fast Atom Bombardment Mass Spectrometry

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概要

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• The investigation of the host-guest complex formations between cyclophane (TGDMAP) (1) as a host and L-acidic amino acids such as L-glutamic acid (Glu) and L-aspartic acid (Asp) as guests was carried out using fast atom bombardment (FAB), electrospray ionization (ESI) and cold-spray ionization (CSI) mass spectrometry (MS). The stability constant (K_S) values obtained by the three different MS methods almost agreed. However, the complex ion peaks of a novel cyclophane (CPCn) (2) with Glu and Asp were not observed in FAB-MS. Then, these host-guest complex formations by use of CSI-MS and ESI-MS was examined, as the results, these complex ion peaks were observed clearly and the measurement values by the two MS methods are mostly in agreement. It was concluded that ESI-MS and CSI-MS are available for the determination of K_S value as well as FAB-MS.

• 公益社団法人日本薬学会の論文
• 2005-08-01

著者

• Motani Kou

  日本大学 薬学部臨床医学ユニット

• YAMAGUCHI Kentaro

  Faculty of Pharmaceutical Sciences at Kagawa Campus, Tokushima Bunnri University

• SEI Yoshihisa

  Faculty of Pharmaceutical Sciences at Kagawa Campus, Tokushima Bunnri University

• Kimura Yumiko

  College Of Pharmacy Nihon University

• Sei Yoshihisa

  Faculty Of Pharmaceutical Sciences At Kagawa Campus Tokushima Bunri University

• Sei Yoshihisa

  Faculty Of Pharmaceutical Sciences At Kagawa Campus Tokushima Bunnri University

• METORI Koichi

  College of Pharmacy, Nihon University

• MIYAKE Muneharu

  College of Pharmacy, Nihon University

• Metori Koichi

  Chemical Analytical Center College Of Pharmacy Nihon University

• Metori Koichi

  College Of Pharmacy Nihon University

• Metori Koichi

  Coll. Of Pharmacy Nihon Univ.

• Miyake Muneharu

  College Of Pharmacy Nihon University

• Miyake Muneharu

  School Of Pharmacy Nihon Univ.

• Yamaguchi Kentaro

  Faculity Of Pharmaceutical Sciences At Kagawa Campus Tokushima Bunri University

• Ozawa Tomoyuki

  Chemical Research Laboratories Nissan Chemical Industries Ltd.

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