Triterpene Alcohols from Camellia and Sasanqua Oils and Their Anti-inflammatory Effects

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概要

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• The nonsaponifiable lipids of camellia and sasanqua oils from the seeds of Camellia japonica L. and C. sasanqua THUNB., respectively, were investigated for their triterpene alcohol constituents. This led to the isolation of twenty-seven triterpene alcohols of which seven were novel naturally occurring compunds, tirucalla-5,7,24-trien-3β-ol (1), lemmaphylla-7,21-dien-3β-ol (2), isoeuphol (3), isotirucallol (4), (24R)-24,25-epoxybutyrospermol (5) and its 24S-epimer (6), and isoaglaiol (7). The structures were determined by spectroscopic and chemical methods. The inhibitory effects of 3,4,a mixture of 5 and 6,a mixture of 7 and its 24S-epimer (aglaiol), and eight known triterpene alcohols isolated in this study were evaluated in ear inflammation in mice induced by 12-O-tetradecanoylphorbol-13-acetate (TPA). The 50% inhibitory dose of these triterpenes for TPA-induced inflammation (1 μg per ear) was 0.2-0.9 mg/ear.

• 公益社団法人日本薬学会の論文
• 1997-12-15

著者

• Akihisa Toshihiro

  College of Science and Technology, Nihon University

• Suzuki T

  Department Of Biochemistry University Of Shizuoka School Of Pharmaceutical Sciences:core Research Fo

• Kimura Y

  Coll. Of Pharmacy Nihon Univ.

• Kimura Yumiko

  College Of Pharmacy Nihon University

• YASUKAWA Ken

  College of Pharmacy, Nihon University

• Suzuki T

  Department Of Pharmaceutics College Of Pharmacy Nihon University

• Suzuki Takashi

  School Of Pharmacy Nihon Univ.

• Yasukawa Ken

  Coll. Of Pharmacy Nihon Univ.

• Yasukawa Ken

  College Of Pharmacy Nihon University

• Akihisa Toshihiro

  College Of Science And Technology Nihon University

• Tai Takaaki

  Morishita Jintan Co. Ltd.

• Tamura T

  Department Of Chemistry And Chemical Engineering Faculty Of Engineering Yamagata University

• YAMANOUCHI Shizuka

  Department of Pharmaceutics, Showa College of Pharmaceutical Sciences

• TAMURA Toshitake

  College of Science and Technology, Nihon University

• TAKASE Sei-ichi

  College of Science and Technology (Funabashi Campus), Nihon University

• YAMANOUCHI Sakae

  College of Pharmacy, Nihon University

• Suzuki Takashi

  Department Of Biochemistry University Of Shizuoka School Of Pharmaceutical Sciences:core Research Fo

• Yamanouchi S

  Department Of Pharmaceutics Showa College Of Pharmaceutical Sciences

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