Enhancement of Water Solubility of Fullerene by Cogrinding with Mixture of Cycloamyloses, Novel Cyclic α-1,4-Glucans, via Solid-Solid Mechanochemical Reaction

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Improvement of solubility for fullerene (C_<60>) was studied by cogrinding with cycloamyloses using a ball mill in the solid state. Cycloamylose is a novel cyclic α-1,4-glucan produced from synthetic amylose by enzymatic reaction. Although sample solutions showed a pale yellow for the initial period of cogrinding with cycloamyloses and C_<60>, the color varied to brown after 48 h. Subsequently, the solubility of C_<60> was improved markedly to 560 (μg/ml) at 96 h. From powder X-ray diffraction analysis, the peak intensity of crystalline C_<60> decreased as the cogrinding time was extended. The UV-VIS absorption spectrum of C_<60> shows absorption bands at 262 and 340 nm in water with cycloamyloses, and 258 and 328 nm in n-hexane. These results suggested that C_<60> molecules were dispersed into cycloamyloses micellar system and the red-shift of the UV-VIS spectra was due to an intermolecular interaction between C_<60> and cycloamyloses.
社団法人日本薬学会の論文
2004-08-01