Novel Channel Structure of Bile Acid-Guest Inclusion Complex Formed between Ursodeoxycholic Acid and Phenanthrene

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概要

• 論文の詳細を見る

• The crystal structure of inclusion complex between ursodeoxycholic acid (UDCA), and phenanthrene has been determined. UDCA molecules formed hydrogen bond network to provide the channel structure along baxis, and phenanthrene molecules were accommodated in the cavity with a stoichiometry of 1 : 1 molar ratio. The channel structure observed in the UDCA-phenanthrene complex was significantly different from that of inclusion complex previously reported for deoxycholic acid (DCA) and cholic acid (CA). Because of the mesh-like hydrogen bond network, channel framework of UDCA could have less flexibility than that of DCA and CA. The difference of molecular state of phenanthrene was clearly observed in solid-state fluorescence measurement.

• 社団法人日本薬学会の論文
• 2003-02-01

著者

• Yamamoto K

  Graduate School Of Pharmaceutical Sciences Chiba University

• YAMAGUCHI KENTARO

  Chemical Analytical Center, Chiba University

• Moribe Kunikazu

  Graduate School of Pharmaceutical Sciences, Chiba University

• Yamamoto Keiji

  Graduate School of Pharmaceutical Sciences, Chiba University

• Yamaguchi K

  Tokushima Bunri Univ. Sanuki‐city Jpn

• TOZUKA Yuichi

  Graduate School of Pharmaceutical Sciences, Chiba University

• OGUCHI Toshio

  Department of Pharmacy, University Hospital, Faculty of Medicine, University of Yamanashi

• Yuichi Tozuka

  Laboratory Of Pharmaceutical Engineering Gifn Pharmaceutical University

• FUKAMI Toshiro

  Graduate School of Pharmaceutical Sciences, Chiba University

• Oguchi T

  Department Of Pharmacy University Hospital University Of Yamanashi

• Oguchi Toshio

  Department Of Pharmacy University Hospital University Of Yamanashi

• Fukami Toshiro

  Department Of Pharmaceutics College Of Pharmacy Nihon University

• Oguchi Toshio

  Faculty Of Pharmaceutical Sciences Chiba University

• Moribe Kunikazu

  Faculty Of Pharmaceutical Sciences Teikyo University

• Moribe Kunikazu

  Graduate School Of Pharmaceutical Sciences Chiba University

• Yamaguchi Kentaro

  Chemical Analysis Center Chiba University

• Yamaguchi Kentaro

  Fac. Of Pharmaceutical Sciences Tokushima Bunri Univ. Kagawa Campus

• Yamamoto Keiji

  Graduate School Of Pharmaceutical Sciences Chiba University

• Yamaguchi Kentaro

  Chemical Analysis Center Chiba Univ. Chiba 263-8522 Jpn

• Moribe Kunikazu

  Graduate School Of Pharmaceutical Sciences Chiba Univ.

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