Effect of Pore Size of FSM-16 on the Entrapment of Flurbiprofen in Mesoporous Structures
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概要
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The interaction between FSM-16 and flurbiprofen (FBP) in the mesopores of FSM-16 was investigated by using three types of FSM-16 with different pore diameters, i.e., FSM-16 (Oc), FSM-16 (Do) and FSM-16 (Doc)(pore diameters 16.0, 21.6, 45.0Å, respectively). Solid dispersions of 30% FBP-70% FSM-16 were prepared by solvent evaporation and sealed-heating of the physical mixture at 100℃ for 6h. Changes in the molecular state of FBP were investigated using powder X-ray diffractometry, thermal analysis and FT-IR spectroscopy. The changes in pore diameter and specific surface area of FSM-16 systems were investigated by small angle X-ray scattering and nitrogen gas adsorption. Powder X-ray diffractometry and thermal analysis revealed that FBP was adsorbed onto the mesopores of FSM-16 (Do) and FSM-16 (Doc), leading to an amorphous state, while no change was observed for FSM-16 (Oc). Fourier-transformed IR spectroscopy showed a hydrogen bond interaction between the carbonyl groups of FBP and the silanol groups of FSM-16. The pore diameter and specific surface area of FSM-16 in solid dispersions decreased due to the adsorption of FBP. Improved dissolution of FBP from solid dispersions prepared by the evaporation and the sealed-heating methods was observed in comparison with FBP crystals.
- 社団法人日本薬学会の論文
- 2005-08-01
著者
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Yamamoto K
Graduate School Of Pharmaceutical Sciences Chiba University
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Moribe Kunikazu
Graduate School of Pharmaceutical Sciences, Chiba University
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Yamamoto Keiji
Graduate School of Pharmaceutical Sciences, Chiba University
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Yamaguchi K
Tokushima Bunri Univ. Sanuki‐city Jpn
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TOZUKA Yuichi
Graduate School of Pharmaceutical Sciences, Chiba University
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Yuichi Tozuka
Laboratory Of Pharmaceutical Engineering Gifn Pharmaceutical University
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WONGMEKIAT Arpansiree
Graduate School of Pharmaceutical Sciences, Chiba University
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KIMURA Kyoko
Graduate School of Pharmaceutical Sciences, Chiba University
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YAMAMURA Shigeo
Faculty of Pharmaceutical Sciences, Toho University
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Yamamura Shigeo
Faculty Of Pharmaceutical Sciences Toho University
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Moribe Kunikazu
Faculty Of Pharmaceutical Sciences Teikyo University
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Moribe Kunikazu
Graduate School Of Pharmaceutical Sciences Chiba University
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Yamaguchi Kentaro
Fac. Of Pharmaceutical Sciences Tokushima Bunri Univ. Kagawa Campus
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Yamamoto Keiji
Graduate School Of Pharmaceutical Sciences Chiba University
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Wongmekiat Arpansiree
Graduate School Of Pharmaceutical Sciences Chiba University
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Kimura Kyoko
Graduate School Of Pharmaceutical Sciences Chiba University
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Moribe Kunikazu
Graduate School Of Pharmaceutical Sciences Chiba Univ.
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