Analysis of Molecular Interactions in Solid Dosage Forms; Challenge to Molecular Pharmaceutics
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概要
- 論文の詳細を見る
The molecular states of active pharmaceutical ingredients (APIs) in pharmaceutical dosage forms strongly affect the properties and quality of a drug. Various important fundamental physicochemical studies were reviewed from the standpoint of molecular pharmaceutics. Mechanochemical effects were evaluated in mixtures of APIs and pharmaceutical additives. Amorphization, complex formation and nanoparticle formation are observed after grinding process depending on the combination of APIs and pharmaceutical additives. Sealed-heating method and mesoporous materials have been used to investigate drug molecular interactions in dosage forms. Molecular states have been investigated using powder X-ray diffraction, thermal analysis, IR, solid state fluorometry, and NMR.
著者
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Moribe Kunikazu
Graduate School of Pharmaceutical Sciences, Chiba University
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Yamamoto Keiji
Graduate School of Pharmaceutical Sciences, Chiba University
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Limwikrant Waree
Graduate School of Pharmaceutical Sciences, Chiba University
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Moribe Kunikazu
Graduate School Of Pharmaceutical Sciences Chiba University
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Yamamoto Keiji
Graduate School Of Pharmaceutical Sciences Chiba University
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Moribe Kunikazu
Graduate School Of Pharmaceutical Sciences Chiba Univ.
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