Characterization and Quantitation of Clarithromycin Polymorphs by Powder X-Ray Diffractometry and Solid-State NMR Spectroscopy

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概要

• 論文の詳細を見る

• Characterization of clarithromycin polymorph was performed by solid-state cross polarization and magic angle spinning (CP/MAS) ^<13>C-NMR spectroscopy. Two polymorphs, form II and form I, of clarithromycins indicated characteristic resonances of C1 carbonyl carbon at 176.2 and 175.2 ppm, respectively. Since each peak of C1 carbon was well separated in the spectrum of the two polymorphs, we performed quantitative analysis of the polymorphic fraction from the peak area of these peaks. The peak area of form I was found to linearly increase with an increase of its content, with a correlation coefficient of above 0.99. Solid-state NMR was found to be a useful technique to determine the characteristics of the polymorphic forms.

• 社団法人日本薬学会の論文
• 2002-08-01

著者

• Yamamoto K

  Graduate School Of Pharmaceutical Sciences Chiba University

• Yamamoto Keiji

  Graduate School of Pharmaceutical Sciences, Chiba University

• Yamaguchi K

  Tokushima Bunri Univ. Sanuki‐city Jpn

• TOZUKA Yuichi

  Graduate School of Pharmaceutical Sciences, Chiba University

• Yuichi Tozuka

  Laboratory Of Pharmaceutical Engineering Gifn Pharmaceutical University

• OGUCHI Toshio

  Graduate School of Pharmaceutical Sciences, Chiba University

• ITO Atsutoshi

  Graduate School of Pharmaceutical Sciences, Chiba University

• SEKI Hiroko

  Chemical Analysis Center, Chiba University

• Oguchi T

  Department Of Pharmacy University Hospital University Of Yamanashi

• Oguchi Toshio

  Faculty Of Pharmaceutical Sciences Chiba University

• Yamaguchi Kentaro

  Fac. Of Pharmaceutical Sciences Tokushima Bunri Univ. Kagawa Campus

• Yamamoto Keiji

  Graduate School Of Pharmaceutical Sciences Chiba University

• Seki H

  Chemical Analysis Center Chiba University

• Seki Hiroko

  Chemical Analysis Centre Chiba University

• Ito Atsutoshi

  Graduate School Of Pharmaceutical Sciences Chiba University

• Seki Hiroko

  Chemical Analysis Center Chiba Univ.

• Ito Atustoshi

  Graduate School of Pharmaceutical Sciences, Chiba University

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