Water Vapor Adsorption Behavior of Sodium Deoxycholate Anhydrous Forms
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概要
- 論文の詳細を見る
Pseudopolymorphism of sodium deoxycholate (NaDC) was investigated. Intact NaDC (dihydrate) was dried at 60 ℃ under reduced pressure resulting an anhydrous amorphous phase. On the other hand, intact NaDC was altered to an anhydrous crystalline form by heating at 200 ℃. The water vapor adsorption and desorption isotherms of dehydrated NaDCs were determined using an automatic gravimetric water vapor adsorption analyzer. In the case of NaDC dehydrated at 60 ℃, the weight was increased in rising relative humidity and it was transformed into the NaDC tetrahydrate above 60% RH, which was identified by TG/DTA and powder X-ray diffraction. During the water vapor adsorption process of the sample dehydrated at 200 ℃, the NaDC dihydrate was obtained in the range of 50 to 70% RH and then transformed into the NaDC octahydrate above 85% RH. The NaDC octahydrate was characterized by TG/DTA and powder X-ray diffraction for the first time. During the desorption process, the octahydrate was changed to the tetrahydrate between 80 and 40% RH.
- 社団法人日本薬学会の論文
- 2005-02-01
著者
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Yamamoto K
Graduate School Of Pharmaceutical Sciences Chiba University
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Moribe Kunikazu
Graduate School of Pharmaceutical Sciences, Chiba University
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Yamamoto Keiji
Graduate School of Pharmaceutical Sciences, Chiba University
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Yamaguchi K
Tokushima Bunri Univ. Sanuki‐city Jpn
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TOZUKA Yuichi
Graduate School of Pharmaceutical Sciences, Chiba University
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OGUCHI Toshio
Department of Pharmacy, University Hospital, Faculty of Medicine, University of Yamanashi
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Ono M
Tokushima Bunri Univ. Tokushima Jpn
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Yuichi Tozuka
Laboratory Of Pharmaceutical Engineering Gifn Pharmaceutical University
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ONO Makoto
Graduate School of Pharmaceutical Sciences, Chiba University
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ANZAI Hiroyuki
Graduate School of Pharmaceutical Sciences, Chiba University
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Oguchi T
Department Of Pharmacy University Hospital University Of Yamanashi
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Oguchi Toshio
Department Of Pharmacy University Hospital University Of Yamanashi
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Ohta Masato
Pharmaceutical Research Center Meiji Seika Kaisha Ltd.
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Oguchi Toshio
Faculty Of Pharmaceutical Sciences Chiba University
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Moribe Kunikazu
Faculty Of Pharmaceutical Sciences Teikyo University
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Moribe Kunikazu
Graduate School Of Pharmaceutical Sciences Chiba University
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Yamaguchi Kentaro
Fac. Of Pharmaceutical Sciences Tokushima Bunri Univ. Kagawa Campus
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Yamamoto Keiji
Graduate School Of Pharmaceutical Sciences Chiba University
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Ono Makoto
Graduate School Of Pharmaceutical Sciences Chiba University:chemical Research Center Daiichi Pharmac
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Anzai Hiroyuki
Graduate School Of Pharmaceutical Sciences Chiba University
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Moribe Kunikazu
Graduate School Of Pharmaceutical Sciences Chiba Univ.
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