Intermolecular Hydrogen Bonding of Steroid Compounds : PFG NMR Diffusion Study, Cold-Spray Ionization (CSI)-MS and X-Ray Analysis

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概要

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• An extensive analysis of hydrogen bonding of steroid compounds in diluted solution is preformed by pulsed field gradient (PFG) NMR and cold-spray ionization (CSI)-MS, in the solid state by X-ray crystallographic analysis. The formation of hydrogen bond interaction are quantified and discussed. Although X-ray analysis in the crystalline state and CSI-MS measurement in solution suggested that the observed diffusion coefficient D_<obs> of the steroid compounds may vary in accordance with the number of hydrogen bonds, the actual observed D_<obs> value determined from the diffusion studies diminished constantly without correlation on the decreasing numbers of hydrogen bonds. Comparison of two different calibration profiles of calculated molecular volume (V_<cal>) vs. D_<obs>, which are obtained from compounds possessing no hydrogen bonding and the steroid compounds, formation of a chain structure (cluster) based on intermolecular hydrogen bonding of the steroid compounds is unambiguously confirmed.

• 社団法人日本薬学会の論文
• 2005-07-01

著者

• Yamamoto K

  Graduate School Of Pharmaceutical Sciences Chiba University

• Yamaguchi K

  Tokushima Bunri Univ. Sanuki‐city Jpn

• SEI Yoshihisa

  Faculty of Pharmaceutical Sciences at Kagawa Campus, Tokushima Bunnri University

• Sei Yoshihisa

  Fac. Of Pharmaceutical Sciences At Kagawa Campus Tokushima Bunnri Univ.

• Sei Yoshihisa

  Faculty Of Pharmaceutical Sciences At Kagawa Campus Tokushima Bunnri University

• SEKI Hiroko

  Chemical Analysis Center, Chiba University

• SAKAMOTO Shigeru

  Chemical Analysis Center, Chiba University

• SHIKII Kazuaki

  Chemical Analysis Centre, Chiba University

• UTSUMI Hiroaki

  NMR Application Lab., JEOL Ltd.

• YAMAGUCHI Kentaro

  CREST, Japan Science and Technology Agency (JST)

• Yamaguchi Kentaro

  Fac. Of Pharmaceutical Sciences Tokushima Bunri Univ. Kagawa Campus

• Sakamoto Shigeru

  Chemical Analysis Center Chiba University

• Seki Hiroko

  Chemical Analysis Centre Chiba University

• Utsumi Hiroaki

  Nm Application & Research Group Application & Research Center Analytical Instruments Divisio

• Shikii Kazuaki

  Chemical Analysis Centre Chiba University

• Sakurai Satoshi

  Chemical Analysis Center Chiba University

• Seki Hiroko

  Chemical Analysis Center Chiba Univ.

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