Inhibition of the Metallo-β-lactamase Produced from Serratia marcescens by Thiol Compounds

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概要

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• Low molecular weight thiol compounds have been found to be strong inhibitors of metallo-β-lactamase (IMP-1) produced by Serratia marcescens TN9106,which was expressed by Echerichia coli JM109 cells. Mercaptoacetic acid and 2-mercaptopropionic acid strongly and competitively inhibited IMP-1 with K_i of 0.23 and 0.19 μM, respectively. 2-Mercaptoethanol reversibly inhibited IMP-1 but did not show simple competitive inhibition.

• 公益社団法人日本薬学会の論文
• 1997-11-15

著者

• OHTA Michio

  Department of Molecular Bacteriology, Nagoya University Graduate School of Medicine

• Goto M

  School Of Pharmaceutical Sciences Kitasato University

• Miura Hirohito

  National Food Research Institute

• Ohta Masato

  Pharmaceutical Research Center Meiji Seika Kaisha Ltd.

• Goto M

  Graduate School Of Pharmaceutical Sciences Kumamoto University

• Goto Masafumi

  Faculty Of Pharmaceutical Sciences Kumamoto University

• ARAKAWA Yoshichika

  National Institute of Infectious Diseases

• Moriya H

  Department Of Pathology Gifu University School Of Medicine

• 森 春樹

  Research Center Mitsui Toatsu Chemicals

• TAKAHASHI Tatsuya

  Faculty of Pharmaceutical Sciences, Kumamoto University

• YAMASHITA Fumiko

  Faculty of Pharmaceutical Sciences, Kumamoto University

• KOREEDA Ako

  Faculty of Pharmaceutical Sciences, Kumamoto University

• MORI Hiromasa

  Faculty of Pharmaceutical Sciences, Kumamoto University

• Koreeda Ako

  Department Of Forensic Medicine Kumamoto University School Of Medicine

• Koreeda Ako

  Faculty Of Pharmaceutical Sciences Kumamoto University

• Ohta Miyako

  Division Of Biological Chemistry And Biologicals National Institute Of Health Sciences

• Mori Hiromasa

  Faculty Of Economics Hosei University

• Ohta Michio

  Department Of Bacteriology Nagoya University Postgraduate School Of Medicine

• Goto Masafumi

  Faculty Of Pharmaceutical Science Kumamoto University

• Arakawa Y

  Department Of Bacterial Pathogenesis And Infection Control National Institute Of Infectious Diseases

• Ohta Michio

  Department Of Bacteriology Graduate School Of Medicine Nagoya University

• Takahashi Tatsuya

  Faculty Of Pharmaceutical Sciences Kumamoto University

• Yamashita Fumiko

  Faculty Of Pharmaceutical Sciences Kumamoto University

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