Comparative Studies on Antitumor Activity of <I>Klebsiella</I> 03 Lipopolysaccharide and Its Polysaccharide Fraction in Mice
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概要
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The antitumor activity of the polysaccharide fraction (OPS) obtained by the acid hydrolysis of <I>Klebsiella</I> O3 Lipopolysaccharide (KO3 LPS) isolated from the culture supernatant of the decapsulated mutant strain LEN-1 (03: K1<SUP>-</SUP>) against both allogeneic tumor and syngeneic tumor systems in mice was compared with that of KO3 LPS. OPS prolonged the life span of MM2-bearing C3H/He mice by intraperitoneal (i.p.) pre- and post-treatment at the doses of 100 and 1000 mg/kg. However, large amounts of OPS were needed to show the antitumor activity as compared with KO3 LPS. OPS showed no growth inhibitory activity against Meth-A sarcoma in BALB/c mice by i.p., intravenous (i.v.) or intratumoral (i.t.) administration. When 1000 mg/kg of OPS was i.p. administered once a day for 10 days, OPS significantly inhibited the tumor growth of Sarcoma-180 solid type tumor. On the other hand, KO3 LPS significantly suppressed the growth of MethA tumor by Lt. administration at the doses of 0.3 and 1.0 mg/kg and showed complete regression in 8 and 9 out of 10 mice, respectively. In MM2 tumor, KO3 LPS also showed complete regression in all mice post-treated by i.p. administration at the dose of 1 .0 mg/kg. These results suggest that OPS has antitumor activity on the tumors used in this study, but the activity was less than that of KO3 LPS.
著者
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Kato Nobuo
Department Of Agricultural Chemistry Faculty Of Agriculture Kyoto University
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KOSHIURA RYOZO
Department of Pharmacology, Hokuriku University School of Pharmacy
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Hasegawa Takaaki
Department Of Hospital Pharmacy Nagoya University School Of Medicine
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Ohta Michio
Department Of Bacteriology Graduate School Of Medicine Nagoya University
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Miyamoto Kenichi
Department Of Chemistry For Materials Faculty Of Engineering And Graduate School Of Engineering Mie
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OHTA Michio
Department of Bacteriology, Nagoya University School of Medicine
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KIDO Nobuo
Department of Bacteriology, Nagoya University School of Medicine
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HASEGAWA Takaaki
Department of Bacteriology, Nagoya University School of Medicine
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