Kinetic Interaction between Theophylline and a Newly Developed Quinolone, NY-198

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概要

• 論文の詳細を見る

• The effect of a newly developed quinolone, NY-198,on the pharmacokinetics and metabolism of theophylline was investigated under steady-state conditions in six male healthy volunteers, in a crossover fashion. A sustained-release theophylline formulation (200 mg twice daily at 12 h intervals) was received as monotherapy or coadministration with NY-198 (200 mg twice daily at 12 h intervals). No significant change in the pharmacokinetic parameters of theophylline was observed during coadministration of NY-198. No significant change in urinary excretion of theophylline and its metabolites was also observed. These findings indicate that NY-198 does not influence the pharmacokinetics of theophylline and we can suggest that quinoline derivatives have less effect on theophylline disposition than 1,8-naphthyridine derivatives among quinolones.

• 社団法人日本薬学会の論文

著者

• Takagi K

  Department Of Medical Technology Nagoya University School Of Health Sciences

• NADAI Masayuki

  Faculty of Pharmacy, Meijo University

• HASEGAWA Takaaki

  Department of Pharmacy and Pharmacokinetics, Aichi Medical University School of Medicine

• KUZUYA Takafumi

  Department of Hospital Pharmacy

• TAKAGI Kenzo

  Second Department of Internal Medicine

• Nadai Masayuki

  Faculty Of Pharmacy Meijo University

• Hasegawa Takaaki

  Department Of Pharmacy And Pharmacokinetics Aichi Medical University School Of Medicine

• Hasegawa Takaaki

  Third Division Of The Research Laboratory For Development Of Medicine School Of Pharmacy Hokuriku Un

• Muraoka Isao

  Department Of Hospital Pharmacy Nagoya University School Of Medicine

• Nadai Masayuki

  Department Of Pharmaceutics Faculty Of Pharmacy Meijo University

• Takagi Kenzo

  Department Of Medical Technology Nagoya University School Of Health Sciences

• APICHARTPICHEAN Ruttikorn

  Department of Hospital Pharmacy, Nagoya University School of Medicine

• Hasegawa Takaaki

  Department Of Hospital Pharmacy Nagoya University School Of Medicine

• Nadai Masayuki

  Department Of Pharmaceutics Facuty Of Pharmacy Meijo University

• Apichartpichean Ruttikorn

  Department Of Hospital Pharmacy Nagoya University School Of Medicine

• HASEGAWA Takaaki

  Department of Bacteriology, Nagoya University School of Medicine

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