Effect of Chitosan on Gastrointestinal Absorption of Water-Insoluble Drugs Following Oral Administration in Rats(Biopharmacy)

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概要

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• Chitosan is widely used as a dietary weight-loss supplement in Japan. In the present study, we examined the effect of chitosan on the gastrointestinal absorption profiles of the water-insoluble drugs, indomethacin and griseofulvin, and the water-soluble drugs, acetaminophen and cephalexin, after oral administration in rats. Rats received oral administration of chitosan (5mg/kg or 25mg/kg) dissolved in 5% acetic acid or vehicle 15 min before oral administration of each drug. Chitosan at a dose of 25mg/kg, but not 5mg/kg, significantly decreased the plasma concentrations of indomethacin and griseofulvin after administration as a suspension with a significant delay of the time to reach maximum concentration compared to the corresponding control values (vehiclepretreated rats). However, pretreatment of chitosan (25mg/kg) did not change the pharmacokmetics of indomethacin administered as a solution. Further, the same dose of chitosan had no effect on the pharmacokmetics of acetaminophen. The gastrointestinal absorption profile of an amino-β-lactam antibiotic, cephalexin, which is actively absorbed via carrier-mediated transport system, was also unchanged. The present findings at least suggest the possibility that chitosan at high dose reduces the gastrointestinal absorption of water-insoluble drugs such as indomethacin and griseofulvin, but not water-soluble drugs, by diminishing the surfactant-like effect of bile acids.

• 公益社団法人日本薬学会の論文
• 2006-09-01

著者

• Suzuki Yuji

  Department of Pubulic Health and Environmental Mesicine,Jikei University School of Medicine

• NADAI Masayuki

  Faculty of Pharmacy, Meijo University

• HASEGAWA Takaaki

  Department of Pharmacy and Pharmacokinetics, Aichi Medical University School of Medicine

• Zhao Ying

  State Key Laboratory Of Biotherapy And Cancer Center West China Hospital West China Medical School S

• Zhao Ying

  Department Of Cardiology Anzhen Hospital Capital Medical University

• KIMURA Masao

  Department of Physical Electronics, Tokyo Institute of Technology

• Nadai Masayuki

  Faculty Of Pharmacy Meijo University

• Hasegawa Takaaki

  Department Of Pharmacy And Pharmacokinetics Aichi Medical University School Of Medicine

• Hasegawa Takaaki

  Third Division Of The Research Laboratory For Development Of Medicine School Of Pharmacy Hokuriku Un

• NADAI Masayuki

  Department of Pharmaceutics, Facuty of Pharmacy, Meijo University

• TSUNEKAWA Yoshimi

  Department of Pharmaceutics, School of Pharmacy, Aichi Gakuin University

• YOSHIZUMI Hideo

  Department of Pharmaceutics, Facuty of Pharmacy, Meijo University

• TAJIRI Chiharu

  Department of Pharmaceutics, Faculty of Pharmacy, Meijo University

• Tajiri Chiharu

  Department Of Pharmaceutics Faculty Of Pharmacy Meijo University

• Nadai Masayuki

  Department Of Pharmaceutics Faculty Of Pharmacy Meijo University

• Yoshizumi Hideo

  Department Of Pharmaceutics Facuty Of Pharmacy Meijo University

• Hasegawa Takaaki

  Department Of Hospital Pharmacy Nagoya University School Of Medicine

• Zhao Ying

  State Key Laboratory Of Biotherapy And Cancer Center West China Hospital West China Medical School S

• Suzuki Yuji

  Department Of Public Health And Environmental Medicine Jikei University School Of Medicine

• Kimura Masao

  Department Of Pharmacy And Pharmacokinetics Aichi Medical University School Of Medicine

• Kimura Masao

  Department Of Ocean Engineering Faculty Of Marine Science And Technology Tokai University

• Tsunekawa Yoshimi

  Department Of Pharmaceutics School Of Pharmacy Aichi Gakuin University

• Kimura Masao

  Department Of Naval Architecture Faculty Of Engineering Yokohama National Univ.

• Suzuki Yuji

  Department Of Mechanical Engineering The University Of Tokyo

• Suzuki Yuji

  Department Of Health Sciences School Of Health And Social Services Saitama Prefectural University

• Suzuki Yuji

  Department Of Pharmacy And Pharmacokinetics Aichi Medical University School Of Medicine

• Suzuki Yuji

  Department Of Astronomy Kyoto University

• Zhao Ying

  Department of Biological Sciences and Biotechnology, Tsinghua University

• KIMURA Masao

  Department of Chemistry, Faculty of Sience, Hokkaido University

• SUZUKI Yuji

  Department of Agriculture, Graduate School of Agricultural Science, Tohoku University

• Kimura Masao

  Department of Chemistry Nagoya University

• NADAI Masayuki

  Department of Hospital Pharmacy, Nagoya University School of Medicine

• HASEGAWA Takaaki

  Department of Bacteriology, Nagoya University School of Medicine

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