Evaluation of Microultrafiltration Devices for Binding Study Using a Small Sample Volume.
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概要
- 論文の詳細を見る
The free fraction of drugs was measured with microultrafiltration devices: UltrafreeC3LGC (UFC; Nihon Millipore Ltd., Tokyo, Japan), Centricut W-10 (CCW; Kurabo Industries Ltd., Osaka, Japan), and MPS-1 (Amicon Corp., Danvers, MA). The drugs tested were phenytoin, carbamazepine, and valproic acid. A 200μl sample volume was used. For two of three drugs, the free fraction by CCW was significantly low, and those by UFC did not show constant values. The free fraction by MPS-1 using a small sample volume (200μl) tended to show high values. The variable values of free fraction of drugs obtained with several devices may be caused by protein leakage, adsorption to the device, etc. The accurate free fraction corrected for protein leakage and adsorption to the device was in good agreement in all devices. The results suggest that physicochemical properties of each drug should be noted when a new device is used to examine protein binding of drugs for routine therapeutic free drug monitoring, especially with a small sample volume. In addition, if needed, it is suggested that the free fraction obtained should be corrected for protein leakage and the adsorption to the device.
著者
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Hayashi Tetsuo
Department Of Hospital Pharmacy Nagoya University School Of Medicine
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Hasegawa Takaaki
Department Of Hospital Pharmacy Nagoya University School Of Medicine
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KITAZAWA Shikifumi
Department of Hospital Pharmacy, Keio University School of Medicine
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JOHNO Ikuo
Pharmacy Services, Kishiwada City Hospital
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OHSHIMA Taeyuki
The Research Laboratory for Development of Medicine, School of Pharmacy, Hokuriku University
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HASEGAWA Takaaki
Department of Bacteriology, Nagoya University School of Medicine
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HAYASHI Tetsuo
Department of Hospital Pharmacy, School of Medicine, Nagoya University
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KITAZAWA Shikifumi
Department of Hospital Pharmacy, Keio University Hospital
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