Effects of <I>Kamikihito</I>, a Traditional Chinese Medicine, on Neurotransmitter Receptor Binding in the Aged Rat Brain Determined by In Vitro Autoradiography (2): Changes in GABA<SUB>A</SUB> and Benzodiazepine Receptor Binding
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概要
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We investigated the effects of the long-term administration of <I>Kamikihito</I> (KKT) on the specific binding of [<SUP>3</SUP>H]muscimol and [<SUP>3</SUP>H]flunitrazepam in the brains of young and aged rats using in vitro quantitative autoradiography. Specific [<SUP>3</SUP>H]muscimol binding in aged rats was decreased in all brain regions examined compared with that in young rats, whereas [<SUP>3</SUP>H]flunitrazepam binding did not change in any of the brain regions. Scatchard analysis revealed that the maximal number of [3H]muscimol binding sites in the cortex and thalamus was significantly decreased in aged rats compared with young rats, while its affinity remained unchanged. Long-term administration of KKT in young rats had no effect on either [<SUP>3</SUP>H]muscimol or [<SUP>3</SUP>H]-flunitrazepam binding. In contrast, the same treatment in aged rats produced a significant increase in [<SUP>3</SUP>H]-flunitrazepam binding to the cortex, caudate/putamen and accumbens, and it tended to decrease the [<SUP>3</SUP>H]-muscimol binding. These results suggest that the selective reduction of specific [<SUP>3</SUP>H]muscimol binding in the brain may be responsible, at least in part, for anxiety-related behavior in aged rats. Furthermore, it appears that the significant increase in specific [<SUP>3</SUP>H]flunitrazepam binding produced in the brains of aged rats by the long-term administration of KKT may be responsible for the anxiolytic effects of this agent.
著者
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Yamada Kiyofumi
Department Of Hospital Pharmacy Nagoya University School Of Medicine
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Nabeshima Toshitaka
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences Meijo University
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Hayashi Tetsuo
Department Of Hospital Pharmacy Nagoya University School Of Medicine
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SHOHMORI Toshikiyo
Department of Neurology Okayama University Mecdical School
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Morimasa Tadaomi
Department Of Neurology Okayama University Medical School
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Kameyama Tsutomu
Department Of Biological Chemistry Faculty Of Pharmaceutical Sciences Nagoya City University
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Kaneyuki Takao
Department of Neurology, Okayama University Medical School
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Ishihara Seiichi
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Meijo University
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HASEGAWA Takaaki
Department of Bacteriology, Nagoya University School of Medicine
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