Effect of Dietary Fiber on Morphine-induced Constipation in Rats(Food & Nutrition Science)
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概要
- 論文の詳細を見る
Morphine is used to alleviate chronic cancer pain. However, constipation is a major adverse effect that often detracts from the patient's quality of life. In this study, we investigated the effectiveness of dietary fiber on morphine-induced constipation. Rats were fed on a normal diet or one containing either 10% or 20% apple fiber for two weeks before morphine was administered. In the control diet group, the fecal number and dry weight were decreased by treating with morphine in a dose-dependent manner. Moreover, the motility of the small and large intestines was reduced. The fecal number and weight were increased and the colon motility was promoted by dietary fiber, regardless of whether morphine was being administered. The dietary fiber increased the concentration of short-chain fatty acids (SC-FAs) in the cecum. These results suggest that dietary fiber has a preventative effect on morphine-induced constipation by increasing SCFAs in the cecum, and thereby promoting colon motility in rats.
- 社団法人日本農芸化学会の論文
- 2002-06-23
著者
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YAMADA Kiyofumi
Department of Neurosurgery, Graduate School of Medicine, Gifu University
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Nabeshima Toshitaka
Department of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, Meijo University, J
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Nakao Makoto
Department Of Pediatric Surgery Reproductive And Developmental Medicine Graduate School Of Medical S
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Nishida M
Department Of Clinical Pharmacy Facutly Of Pharmacy Meijo University
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Nishida Mikio
Department Of Clinical Pharmacy Faculty Of Pharmacy Meijo University
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Yamada Kiyofumi
Department Of Hospital Pharmacy Nagoya University School Of Medicine
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NIWA Takashi
Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Me
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HOSHI Seiko
Department of Nutritional Research, Nutrition Science Institute, Meiji Milk Products Co. Ltd
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INAGAKI Kazuhiro
Department of Clinical Pharmacy, Facutly of Pharmacy, Meijo University
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Nabeshima Toshitaka
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences Meijo University
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Hoshi Seiko
Department Of Nutritional Research Nutrition Science Institute Meiji Milk Products Co. Ltd
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Niwa Takashi
Department Of Neuropsychopharmacology And Hospital Pharmacy Nagoya University Graduate School Of Med
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Inagaki Kazuhiro
Department Of Clinical Pharmacy Facutly Of Pharmacy Meijo University
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Inagaki Kazuhiro
Department Of Clinical Pharmacy Faculty Of Pharmacy Meijo University
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Nakao M
Univ. Hyogo Hyogo Jpn
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Nishida Mikio
Department Of Biochemistry Faculty Of Pharmaceutical Sciences University Of Tokushima
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Nakao Makoto
Department Of Electrical Engineering Shinshu University
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Yamada Kiyofumi
Department Of Neuropsychopharmacology And Hospital Pharmacy Nagoya University Graduate School Of Med
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Nabeshima Toshitaka
Department Of Neuropsychopharmacology And Hospital Pharmacy Nagoya University Graduate School Of Med
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