Participation of Endogenous Dehydroepiandrosterone and Its Sulfate in the Pathology of Collagen-Induced Arthritis in Mice(Misellaneous)
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概要
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We have investigated the serum levels of dehydroepiandrosterone (DHEA) and DHEA sulfate (DHEAS) in type II collagen (CII)-induced arthritis (CIA) DBA/1J mice, an experimental model of human rheumatoid arthritis (RA). Serum levels of DHEA and DHEAS were measured by EIA and GC/MS, respectively. Sera were obtained from the mice on day 6, 13, 28 and 48 after the CII treatment. The disease onset of CIA was observed from day 28 (7%) to day 48 (80%) after CII immunization. The serum concentration of DHEA on day 13 did not differ from that on day 6 in CIA mice and untreated controls. Serum levels of DHEA on day 28 and 48 were significantly low compared with those on day 6 in controls. However, in CIA mice, DHEA levels on day 28 and 48 were not decreased from those on day 6. No difference in the serum DHEAS level on day 13 compared with day 6 was observed in either control or CIA mice. A significant decrease of DHEAS levels on day 28 and 48 compared with day 6 was found in both groups. The time point for the retention of DHEA in CIA mice, day 28 and day 48, coincided with the disease onset of CIA. In conclusion, endogenous DHEA may be produced as a result of physiological response for the protection against CIA.
- 公益社団法人日本薬学会の論文
- 2003-11-01
著者
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西田 昌代
Meiji College of Pharmacy
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Nishida Makiko
崇城大学 薬学部薬学科
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Nishida Makiko
Faculty Of Engineering Kyushu Kyoritsu University
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OKAMOTO Yoshihiro
Department of Health Promotion and Preventive Medicine, Nagoya City University Graduate School of Me
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Nishida M
Department Of Clinical Pharmacy Faculty Of Pharmacy Meijo University
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Nishida Mikio
Department Of Clinical Pharmacy Faculty Of Pharmacy Meijo University
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Okamoto Y
Graduate School Of Science And Engineering Ehime University
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Okamoto Y
Department Of Clinical Pharmacy Faculty Of Pharmacy Meijo University
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Yasui Kohichiroh
愛生会山科病院 内科
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Yasui Koichiro
Molecular Gastroenterology And Hepatology Kyoto Prefectural University Of Medicine Graduate School O
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Yasui Kohichiroh
Molecular Gastroenterology And Hepatology Kyoto Prefectural University Of Medicine Graduate School O
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Kobayashi Yoshiharu
Tokyo University of Pharmacy and Life Science
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NISHIDA Miharu
Department of Analytical Chemistry of Medicines, Showa Pharmaceutical University
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Kobayashi Yoshiharu
Clinical Chemistry And Medicinal Chemistry Laboratories Kobe Women's College Of Pharmacy
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TAGAWA Noriko
Clinical Chemistry Laboratory
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Tagawa Noriko
神戸薬科大学 病態生化学研究室
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MURAOKA Kimie
Clinical Chemistry Laboratory, Kobe Pharmaceutical University
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Muraoka Kimie
Clinical Chemistry Laboratory Kobe Pharmaceutical University
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Okamoto Yoshihiro
Department Of Clinical Pharmacy Faculty Of Pharmacy Meijo University
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Okamoto Yoshihiro
Graduate School Of Science And Engineering Ehime University
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Nishida Mikio
Department Of Biochemistry Faculty Of Pharmaceutical Sciences University Of Tokushima
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Yoshida Kyotaro
Dep. Of Medical Biochemistry Kobe Pharmaceutical Univ.
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Okamoto Yoshihiro
Department of Chemistry, Faculty of Engineering Science, Osaka University
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