Diastereoselective (Ethoxycarbonyl)difluoromethylation of Chiral Imide Enolates Mediated by Triethylborane
スポンサーリンク
概要
- 論文の詳細を見る
Triethylborane-mediated reactions of lithium enolates derived from chiral N-acyloxazolidinones with ethyl difluoroiodoacetate allows easy access to α-(ethoxycarbonyl)difluoromethylated carboximides with good diastereomeric excess (86->98%de). The stereochemistry of the (ethyoxycarbonyl)difluoromethylated carboximides indicates that the (ethoxycarbonyl)difluoromethyl radical generated from ethyl difluoroiodoacetate and triethylborane reacts preferentially on the si face of the lithium enolates.
- 公益社団法人日本薬学会の論文
- 1996-07-15
著者
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NAGAI Takabumi
MEC Laboratory, Daikin Industries, Ltd.
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Nagai Takabumi
Mec Laboratory Daikin Industries Ltd.
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Yasui Koichiro
Molecular Gastroenterology And Hepatology Kyoto Prefectural University Of Medicine Graduate School O
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Yasui Kohichiroh
Molecular Gastroenterology And Hepatology Kyoto Prefectural University Of Medicine Graduate School O
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Kobayashi Yoshiharu
Tokyo University of Pharmacy and Life Science
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Takahashi Mie
Mec Laboratory Daikin Industries Ltd.
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ISEKI Katsuhiko
MEC Laboratory, Daikin Industries, Ltd.
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KOBAYASHI Yoshiro
MEC Laboratory, Daikin Industries, Ltd.
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ASADA Daisuke
MEC Laboratory, Daikin Industries, Ltd.,
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Asada Daisuke
Mec Laboratory Daikin Industries Ltd.
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Iseki K
Mec Laboratory Daikin Industries Ltd.
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Yoshida Kyotaro
Dep. Of Medical Biochemistry Kobe Pharmaceutical Univ.
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